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Keywords: Mitosis
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Journal Articles
Biol Open bio.059277.
Published: 9 June 2022
... of roles in an intact animal. Chromosome segregation Germline Inner centromere Meiosis Mitosis Spermatogenesis M.J. Murdock Charitable Trust https://dx.doi.org/10.13039/100000937 NS-201913963 Genetic analysis of C. elegans Haspin-like genes shows that hasp-1 plays multiple roles...
Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... and tumorigenic phenotypes are worsened by aneuploidy induction in adult stem cells in the Drosophila intestinal epithelium. Cancer Mitosis Aneuploidy Stem cells Spindle assembly checkpoint European Regional Development Fund http://dx.doi.org/10.13039/501100008530 Fundação para...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (7): bio053322.
Published: 21 July 2020
... into mitosis after UV irradiation . J. Cell Sci.   130 , 4028 - 4037 . 10.1242/jcs.204693 Saitoh , S. and Yanagida , M. ( 2014 ). Does a shift to limited glucose activate checkpoint control in fission yeast?   FEBS Lett.   588 , 2373 - 2378 . 10.1016/j.febslet.2014.04.047...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (6): bio037424.
Published: 12 June 2019
... the nuclear envelope disassembles during mitosis, MCCs diffuse throughout the spindle region and cytoplasm. Here, we employed an approach using binucleate yeast zygotes to examine the localization dynamics of SAC effectors required for MCC assembly and function in budding yeast, in which the nuclear envelope...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (12): bio038307.
Published: 14 December 2018
... to asparaginase treatment. Together, these results argue that human asparagine synthetase undergoes regulated recruitment to the mitotic spindles and that it may have acquired a second role in mitosis similar to other metabolic enzymes that contribute to metabolic reprogramming in cancer cells. * Author...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (11): 1672–1679.
Published: 5 October 2017
... regulates chromosome movement and the metaphase-to-anaphase cell cycle transition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information. Mitosis Spindle checkpoint Cell cycle Microtubules Anaphase-promoting complex...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (6): 844–849.
Published: 28 April 2017
...Lan Lin; Li Chen; Phong T. Tran ABSTRACT Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation. It has been recently recognized that another type of protein modification...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (5): 654–663.
Published: 28 March 2017
...Jack W. C. Chen; Zhuo A. Chen; Kacper B. Rogala; Jeremy Metz; Charlotte M. Deane; Juri Rappsilber; James G. Wakefield ABSTRACT The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (3): 390–401.
Published: 20 January 2017
..., we applied our method to time-lapse data of mh embryos. We discovered that haploid nuclei in mh embryos can collide during the syncytial blastoderm to give rise to diploid and polyploid nuclei that persist until gastrulation and resume mitosis. Being able to track synchronized nuclei of different...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (11): 1674–1679.
Published: 15 November 2016
... of BubR1 leads to accelerated mitosis. We previously found that mutation of the KEN1-box domain of Drosophila BubR1 ( bubR1-KEN1 mutant) affects the binding of BubR1 to Cdc20, the activating co-factor of the APC/C, and does not accelerate the mitotic timing despite resulting in a defective SAC, which...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (8): 1052–1061.
Published: 24 July 2015
..., although mitosis is largely unperturbed and these embryos develop and hatch at near-normal rates. Y2H analysis reveals that PLP can potentially form multiple interactions with itself and with the PCM recruiting proteins Asl, Spd-2 and Cnn. A deletion analysis suggests that PLP participates in a complex...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (2): 155–169.
Published: 16 January 2015
..., large-scale immunoprecipitation and mass spectrometry, we report the first comprehensive map of mitotic phase-specific protein interactions of the microtubule-end binding protein, EB1. EB1 interacts with some, but not all, of its partners throughout mitosis. We show that the interaction of EB1...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (12): 1217–1223.
Published: 21 November 2014
... ). For experiments with small molecule inhibitors, the proteasome inhibitor MG132, the Eg5 inhibitor STLC and taxol were used at a final concentration of 10 µM, 10 µM and 1 µM respectively. K-fiber Clasp Microtubules Mitosis Spindle The self-organization and maintenance of a bipolar spindle...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (10): 904–912.
Published: 12 September 2014
...Takahiro Matsusaka; Maria Enquist-Newman; David O. Morgan; Jonathon Pines ABSTRACT The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (6): 522–528.
Published: 29 May 2014
... neuroblasts arrest in mitosis when treated with colchicine. cenp-metaΔ mutant cells display a mitotic delay. Yet, despite the persistence of the two checkpoint proteins Mad2 and BubR1 on unattached kinetochores, these cells eventually enter anaphase and give rise to highly aneuploid daughter cells. Indeed, we...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (3): 314–323.
Published: 17 January 2013
... pericentriolar proteins D-PLP, Centrosomin and γ-tubulin. They show poorly focused spindle poles that reach the plasma membrane. Despite being compromised for functional centrosome, these cells could successfully undergo mitosis. Live-cell imaging analysis of acentriolar spindle assembly revealed that nascent...
Journal Articles
Biol Open (2012) 1 (5): 422–429.
Published: 6 March 2012
.../licenses/by-nc-sa/3.0/ ). Dgp71WD Centrosome Mitosis Meiosis Bipolar spindle formation depends on MT polymerisation occurring in a spatially and temporally controlled manner. In many cell types, centrosomes are the primary MT organising centres, however centrosomes are not the only...
Includes: Multimedia, Supplementary data