... Lactate Mitosis Metabolism Council of Scientific and Industrial Research, India http://dx.doi.org/10.13039/501100001412 University Grants Commission http://dx.doi.org/10.13039/501100001501 Department of Science and Technology, Ministry of Science and Technology, India...

... Development Fund http://dx.doi.org/10.13039/501100008530 Cancer Mitosis Aneuploidy Stem cells Spindle assembly checkpoint Summary: Dysplastic and tumorigenic phenotypes are worsened by aneuploidy induction in adult stem cells in the Drosophila intestinal epithelium. © 2021...

... into mitosis after UV irradiation . J. Cell Sci.   130 , 4028 - 4037 . 10.1242/jcs.204693 Saitoh , S. and Yanagida , M. ( 2014 ). Does a shift to limited glucose activate checkpoint control in fission yeast?   FEBS Lett.   588 , 2373 - 2378 . 10.1016/j.febslet.2014.04.047...

... the nuclear envelope disassembles during mitosis, MCCs diffuse throughout the spindle region and cytoplasm. Here, we employed an approach using binucleate yeast zygotes to examine the localization dynamics of SAC effectors required for MCC assembly and function in budding yeast, in which the nuclear envelope...

... to asparaginase treatment. Together, these results argue that human asparagine synthetase undergoes regulated recruitment to the mitotic spindles and that it may have acquired a second role in mitosis similar to other metabolic enzymes that contribute to metabolic reprogramming in cancer cells. * Author...

...-associated (Ska) complex regulates chromosome movement and the metaphase-to-anaphase cell cycle transition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information. Mitosis Spindle checkpoint Cell cycle Microtubules Anaphase...

...Lan Lin; Li Chen; Phong T. Tran ABSTRACT Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation. It has been recently recognized that another type of protein modification...

...Jack W. C. Chen; Zhuo A. Chen; Kacper B. Rogala; Jeremy Metz; Charlotte M. Deane; Juri Rappsilber; James G. Wakefield ABSTRACT The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis...

... reveals cell division genes . Nature   464 , 721 - 727 . 10.1038/nature08869 Philp , A. V. , Axton , J. M. , Saunders , R. D. and Glover , D. M. ( 1993 ). Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid...

... of BubR1 leads to accelerated mitosis. We previously found that mutation of the KEN1-box domain of Drosophila BubR1 ( bubR1-KEN1 mutant) affects the binding of BubR1 to Cdc20, the activating co-factor of the APC/C, and does not accelerate the mitotic timing despite resulting in a defective SAC, which...

..., although mitosis is largely unperturbed and these embryos develop and hatch at near-normal rates. Y2H analysis reveals that PLP can potentially form multiple interactions with itself and with the PCM recruiting proteins Asl, Spd-2 and Cnn. A deletion analysis suggests that PLP participates in a complex...

..., large-scale immunoprecipitation and mass spectrometry, we report the first comprehensive map of mitotic phase-specific protein interactions of the microtubule-end binding protein, EB1. EB1 interacts with some, but not all, of its partners throughout mitosis. We show that the interaction of EB1...

... Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. K-fiber Clasp Microtubules Mitosis Spindle The self-organization and maintenance...

...Takahiro Matsusaka; Maria Enquist-Newman; David O. Morgan; Jonathon Pines ABSTRACT The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis...

... neuroblasts arrest in mitosis when treated with colchicine. cenp-metaΔ mutant cells display a mitotic delay. Yet, despite the persistence of the two checkpoint proteins Mad2 and BubR1 on unattached kinetochores, these cells eventually enter anaphase and give rise to highly aneuploid daughter cells. Indeed, we...

... pericentriolar proteins D-PLP, Centrosomin and γ-tubulin. They show poorly focused spindle poles that reach the plasma membrane. Despite being compromised for functional centrosome, these cells could successfully undergo mitosis. Live-cell imaging analysis of acentriolar spindle assembly revealed that nascent...

.../licenses/by-nc-sa/3.0/ ). Dgp71WD Centrosome Mitosis Meiosis Bipolar spindle formation depends on MT polymerisation occurring in a spatially and temporally controlled manner. In many cell types, centrosomes are the primary MT organising centres, however centrosomes are not the only...