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Keywords: Mitochondria
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Journal Articles
Biol Open (2021) 10 (5): bio058613.
Published: 20 May 2021
... regimes. As such, there is an urgent need to develop new antimicrobial agents that can combat these multidrug-resistant superbugs. Mitochondria are central regulators of metabolism and other cellular functions, including the regulation of innate immunity pathways involved in the defense against infection...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (12): bio056747.
Published: 16 December 2020
... tissue between wild-type and knockout mice. However, mitochondria isolated from brown fat of cd47 deficient mice had significantly higher rates of free fatty acid-mediated uncoupling. This suggests that enhanced fuel availability via white adipose tissue lipolysis may perpetuate elevated brown adipose...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (12): bio054262.
Published: 3 December 2020
... [grant no. 105-2628-B-001-004-MY3]. References Akabane , S. , Uno , M. , Tani , N. , Shimazaki , S. , Ebara , N. , Kato , H. , Kosako , H. and Oka , T. ( 2016 ). PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (9): bio049569.
Published: 3 September 2020
... License ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. GFP tagged mitochondria fly stock: UAS-Mito-GFP/CyO (ChrII) is a transgenic fly line expressing a GFP tagged N...
Journal Articles
Biol Open (2020) 9 (5): bio048629.
Published: 3 May 2020
...Susana Ponte; Lara Carvalho; Maria Gagliardi; Isabel Campos; Paulo J. Oliveira; António Jacinto ABSTRACT Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (1): bio047530.
Published: 14 January 2020
... to other organelles, whereas mitochondria generate energy in the form of ATP. Mitochondria and the ER form physical interactions, defined as mitochondria–ER contact sites (MERCs) to exchange metabolites such as calcium ions (Ca 2+ ) and lipids. Sites of contact between mitochondria and the ER can regulate...
Journal Articles
Biol Open (2019) 8 (10): bio044347.
Published: 15 October 2019
... influx in mcu −/− zebrafish. We also used in vivo calcium imaging and fluorescent assays in purified mitochondria to investigate mitochondrial calcium dynamics in a pink1 −/− zebrafish model of PD. Mitochondrial morphology was evaluated in DA neurons and muscle fibers using immunolabeling and transgenic...
Journal Articles
Biol Open (2019) 8 (7): bio042135.
Published: 19 July 2019
... . 10.3390/ijms20010212 Summary: Overexpression of spargel , the fly PGC-1 homologue proposed as a mitochondrial biogenesis regulator, has minimal effects on the phenotype of tko 25t , considered a fly model for mitochondrial disease. Mitochondria Mitochondrial biogenesis Mitochondrial...
Journal Articles
Biol Open (2019) 8 (5): bio041467.
Published: 9 May 2019
...Gigi Y. Lau; Nicholas Barts; Richard C. Hartley; Michael Tobler; Jeffrey G. Richards; Michael P. Murphy; Sabine Arndt ABSTRACT In this paper, we outline the use of a mitochondria-targeted ratiometric mass spectrometry probe, MitoA, to detect in vivo changes in mitochondrial hydrogen sulfide (H 2 S...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (2): bio041244.
Published: 18 February 2019
... CN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (11): bio033852.
Published: 16 November 2018
... Cunningham , C.C. and Bailey , S.M. ( 2001 ). Ethanol consumption and liver mitochondria function . Biol. Signals Recept.   10 , 271 - 282 . 10.1159/000046892 Cunningham , J. T. , Rodgers , J. T. , Arlow , D. H. , Vazquez , F. , Mootha , V. K. and Puigserver , P...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (11): bio036632.
Published: 31 October 2018
.... Embryol.   34 , 339 - 342 . 10.1111/j.1439-0264.2005.00612.x Kim , M. J. , Kang , K. H. , Kim , C.-H. and Choi , S.-Y. ( 2008 ). Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP . BioTechniques   45 , 331 - 334 . 10.2144...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (12): 1831–1839.
Published: 14 November 2017
... of the mitochondria, their morphology, and their respiration in human dermal fibroblasts. Here, we use this protocol to investigate applicability of power law diffusion to describe mitochondrial locomotion, assessment of rates of fission and fusion in healthy and diseased cells, and differences in mitochondria...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (10): 1483–1492.
Published: 24 August 2017
... downregulated in this breed. Skeletal muscle Myostatin Mitochondria Genomics Myogenesis ...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (6): 741–751.
Published: 15 June 2017
...) hardly induced stalk cell differentiation under the same conditions. Microscopic analyses revealed that the biologically active derivative, DIF-1-BODIPY, was incorporated by stalk cells at late stages of differentiation and was localized to mitochondria. The mitochondrial uncouplers carbonyl cyanide m...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (2): 141–147.
Published: 23 December 2016
...Susann Lehmann; Samantha H. Y. Loh; L. Miguel Martins ABSTRACT Familial forms of Parkinson's disease (PD) caused by mutations in PINK1 are linked to mitochondrial impairment. Defective mitochondria are also found in Drosophila models of PD with pink1 mutations. The co-enzyme nicotinamide adenine...
Journal Articles
Biol Open (2017) 6 (1): 50–58.
Published: 1 December 2016
... - 309 . 10.1196/annals.1293.029 Barth , E. , Stammler , G. , Speiser , B. and Schaper , J. ( 1992 ). Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man . J. Mol. Cell. Cardiol.   24 , 669 - 681...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (8): 1093–1101.
Published: 11 July 2016
... after abrupt salinity transfer . Am. J. Physiol. Cell Physiol. 287 , C300 - C309 . 10.1152/ajpcell.00054.2004 Seo , M. Y. , Lee , K. M. and Kaneko , T. ( 2009 ). Morphological changes in gill mitochondria-rich cells in cultured Japanese eel Anguilla japonica acclimated...
Journal Articles
Biol Open (2016) 5 (7): 962–969.
Published: 22 June 2016
... ). Calcium uptake by rat kidney mitochondria . Proc. Natl. Acad. Sci. USA 47 , 1744 - 1750 . 10.1073/pnas.47.11.1744 Drago , I. , Pizzo , P. and Pozzan , T. ( 2011 ). After half a century mitochondrial calcium in- and efflux machineries reveal themselves . EMBO J. 30 , 4119...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (4): 443–451.
Published: 9 March 2016
... phosphorylation capacity of mitochondria, assessed using permeabilized muscle fibers, increased by a non-significant 47% in alligator thigh and a non-significant 50% in turtle thigh over 30 days, but did not increase in the heart. This developmental trajectory of mitochondrial function is slower and shallower...