... intestinal development. Zebrafish contain two paralogous genes, fip5a and fip5b , that are orthologs of human FIP5 . We find that fip5a - and fip5b -mutant fish show phenotypes characteristic of microvillus inclusion disease, including microvilli defects and lysosomal accumulation. Single and double mutant...

...Nagananda Gurudev; Michaela Yuan; Elisabeth Knust ABSTRACT The apical surface of epithelial cells is often highly specialised to fulfil cell type-specific functions. Many epithelial cells expand their apical surface by forming microvilli, actin-based, finger-like membrane protrusions. The apical...