...Ayaka Shibamoto; Yoshiaki Kitsu; Keiko Shibata; Yuka Kaneko; Harune Moriizumi; Tomoko Takahashi ABSTRACT Viral infectivity depends on multiple factors. Recent studies showed that the interaction between viral RNAs and endogenous microRNAs (miRNAs) regulates viral infectivity; viral RNAs function...

...Douglas M. McLaurin; Sara K. Tucker; Michael D. Hebert ABSTRACT MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate gene expression. An important step in miRNA biogenesis occurs when primary miRNAs are bound and cleaved by the microprocessor to generate precursor miRNAs. Regulation...

... and expression patterns. In a hybrid analysis of the phylogenetic tree, microRNA targets, and expression patterns of SmARFs in different organs, root tissues, and methyl jasmonate or indole-3-acetic acid treatment conditions, we screened for candidate SmARFs involved in various developmental processes of S...

...Rui Chen; Huan Liu; Quan Cheng; Bing Jiang; Renjun Peng; Qin Zou; Wenren Yang; Xiaosheng Yang; Xiaobing Wu; Zigui Chen ABSTRACT MicroRNAs (miRNAs), a class of small non-coding RNAs, can induce mRNA degradation or repress translation by binding to the 3′-untranslated region (UTR) of its target mRNA...

...Frederique Zindy; Daisuke Kawauchi; Youngsoo Lee; Olivier Ayrault; Leila Ben Merzoug; Peter J. McKinnon; Andrea Ventura; Martine F. Roussel ABSTRACT The miR-17∼92 cluster family is composed of three members encoding microRNAs that share seed sequences. To assess their role in cerebellar...

... . Yorkie further mediates reaper levels post-transcriptionally through regulation of members of the miR-2 microRNA family to prevent apoptosis. These findings provide evidence that the Hippo pathway acts via several distinct routes to limit proliferation-induced apoptosis. Authors for correspondence...

... downregulated by spherical cell shape. Network analysis revealed that HNF-4α would elicit both the enhancement of hepatocyte-specific gene expression and suppression of malignancy. Since HNF-4α gene expression was known to be regulated by microRNA, we inferred that spherical cell shape would induce HNF-4α gene...

... ability to orchestrate key signal transduction events and promote cell motility. To identify novel downstream effectors of β4 function in breast cancer, microRNAs (miRNAs) were examined because of their extensive links to tumorigenesis and their ability to regulate gene expression globally. Two breast...

...Anne Karine Lagendijk; Jon D. Moulton; Jeroen Bakkers Summary Non-coding microRNA (miRNA) molecules bind their target mRNAs and thereby modulate the amount of protein produced. To understand the significance of a potential miRNA-mRNA interaction, temporal and spatial information on miRNA and mRNA...