... at this step is essential and one such regulator includes m 6 A RNA methylation, an RNA modification found on primary miRNAs that is installed by METTL3 and bound by hnRNPA2B1. Our lab has recently discovered that the Cajal body marker protein coilin also participates in miRNA biogenesis and hypothesized...

...Chen Tao; Jia Liu; Ziqi Li; Pinglin Lai; Sheng Zhang; Jiankun Qu; Yujin Tang; Anling Liu; Zhipeng Zou; Xiaochun Bai; Jianwei Li ABSTRACT The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1...

...) and DNA-methylation analyses performed on the same chorionic villous samples at 7–8 ( n =8) and 13–14 ( n =6) weeks of gestation. Reads were adjusted for fetal sex. Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix...

... non-inflammatory molecule 1 (vannin-1, encoded by the Vnn1 gene) and its downstream signaling in IUGR asthmatic mice induced by ovalbumin. Significant histological alterations and an increase of vannin-1 expression were revealed in IUGR asthmatic mice, accompanied by elevated methylation of Vnn1...

...Tal Frolinger; Francis Herman; Ali Sharma; Steven Sims; Jun Wang; Giulio Maria Pasinetti ABSTRACT In this study, we developed an experimental protocol leveraging enhanced reduced representation bisulphite sequencing to investigate methylation and gene expression patterns in the hippocampus...

... become part of RNPs we term regulatory RNPs (regRNPs). Most modifications within rRNA (predominantly pseudouridylation and ribose 2′- O -methylation) are conducted by small nucleolar RNPs (snoRNPs), and we provide evidence that the activity of at least some of these snoRNPs is under the control...