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Keywords: Metastasis
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Journal Articles
Biol Open (2022) 11 (12): bio059623.
Published: 13 December 2022
... heterogeneous tumor phenotypes relate to drug response. Here we present syngeneic graft models of aggressive, metastasis-prone histopathology-specific NSCLC tumor types driven by KRAS mutation and loss of LKB1 (KL): adenosquamous carcinoma (ASC) and adenocarcinoma (AC). We show that subcutaneous injection...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2021) 10 (4): bio058566.
Published: 20 April 2021
... common metastatic site. To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. Mice underwent intrarenal implantation using luciferase...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (8): bio042937.
Published: 1 August 2019
...Haijiang Qiu; Fangchao Chen; Minjun Chen ABSTRACT Melanoma with rapid progression towards metastasis has become the deadliest form of skin cancer. However, the mechanism of melanoma growth and metastasis is still unclear. Here, we found that miRNA-138 was lowly expressed and hypoxia-inducible...
Journal Articles
Biol Open (2018) 7 (1): bio030817.
Published: 11 January 2018
... and reveal EphB6 as a metastasis suppressor . Mol. Cancer Res.   12 , 1303 - 1313 . 10.1158/1541-7786.MCR-13-0673 Bailey , C. M. , Morrison , J. A. and Kulesa , P. M. ( 2012 ). Melanoma revives an embryonic migration program to promote plasticity and invasion . Pigment Cell Melanoma...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2016) 5 (10): 1371–1379.
Published: 19 August 2016
... their propensity to metastasise. These studies combine to provide a body of experimental evidence which link alterations to the tRNA repertoire to tumour progression in vivo , and further investigation into these processes will likely contribute to effective strategies to oppose cancer progression and metastasis...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (3): 289–299.
Published: 12 February 2016
... metastatic cells with near perfect accuracy. Thus, subtle changes in shape carry information about the genetic changes that lead to invasiveness and metastasis of osteosarcoma cancer cells. * These authors contributed equally to this work ‡ Author for correspondence ( ashokp@engr.colostate.edu...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (10): 924–936.
Published: 12 September 2014
... with metastasis, but the mechanism by which a cell becomes invasive remains unclear. Expression of p85β, a regulatory subunit of phosphoinositide-3-kinase, markedly increases in advanced carcinoma, but its mode of action is unknown. We postulated that p85β might facilitate cell invasion. We show that p85β...
Includes: Multimedia, Supplementary data