... heterogeneous tumor phenotypes relate to drug response. Here we present syngeneic graft models of aggressive, metastasis-prone histopathology-specific NSCLC tumor types driven by KRAS mutation and loss of LKB1 (KL): adenosquamous carcinoma (ASC) and adenocarcinoma (AC). We show that subcutaneous injection...

... approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal tumors, vascular invasion, metastasis, and circulating tumor cells (CTCs). HepT1 cells were injected into the livers...

... common metastatic site. To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. Mice underwent intrarenal implantation using luciferase...

...Haijiang Qiu; Fangchao Chen; Minjun Chen ABSTRACT Melanoma with rapid progression towards metastasis has become the deadliest form of skin cancer. However, the mechanism of melanoma growth and metastasis is still unclear. Here, we found that miRNA-138 was lowly expressed and hypoxia-inducible...

... information. Nerve growth factor Human Melanoma Metastasis Chick embryonic microenvironment Neural crest Multipotent neural crest cells migrate aggressively, but in a controlled manner, in discrete streams throughout the embryo to contribute to vertebrate organogenesis ( Kulesa and Gammill...

... lead to increases in HIFα expression in humans ( Hu et al., 2003 ; Zerrouqi et al., 2014 ). Given that primary tumours commonly metastasise to the lung, and that levels of these thrombotic markers (along with levels of HIF1α and HIF2α) accurately predict distant metastasis-free survival, we propose...

... their propensity to metastasise. These studies combine to provide a body of experimental evidence which link alterations to the tRNA repertoire to tumour progression in vivo , and further investigation into these processes will likely contribute to effective strategies to oppose cancer progression and metastasis...

... metastatic cells with near perfect accuracy. Thus, subtle changes in shape carry information about the genetic changes that lead to invasiveness and metastasis of osteosarcoma cancer cells. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected]...

... with metastasis, but the mechanism by which a cell becomes invasive remains unclear. Expression of p85β, a regulatory subunit of phosphoinositide-3-kinase, markedly increases in advanced carcinoma, but its mode of action is unknown. We postulated that p85β might facilitate cell invasion. We show that p85β...