...Toshiaki Hino; Hirokazu Kusakabe ABSTRACT Chromosome segregation errors during oocyte meiosis increase with age and lead to aneuploidy; hence, the mechanism has been studied extensively. The mouse is the most widely used experimental animal for this purpose. However, the lack of a reliable...

.... Summary: Our study shows cytogenetic characteristics of Loricariidae from the Xingu River, Brazilian Amazon. Some of these fish are endangered, so this information can help conservation programs for these animals. Repetitive DNA Meiosis Histone Fish U2 snDNA Conselho Nacional de...

...Christopher M. Yellman ABSTRACT Eukaryotic meiosis is a specialized cell cycle of two nuclear divisions that give rise to haploid gametes. The phosphatase Cdc14 is essential for meiosis in the yeast Saccharomyces cerevisiae . Cdc14 is sequestered in the nucleolus, a nuclear domain containing...

... meiosis. Genetic analysis suggests that hasp-1 acts downstream of the Polo-like kinase plk-2 and shows synthetic interactions between hasp-1 and two genes expected to promote recruitment of the CPC by a parallel pathway that depends on the kinase Bub1. This work adds to the growing understanding of Haspin...

...Xinyi Mu; Jia Wen; Qian Chen; Zhengpin Wang; Yijing Wang; Meng Guo; Yi Yang; JinRui Xu; Zhiqing Wei; Guoliang Xia; Mengye Yang; Chao Wang ABSTRACT Lanosterol 14 α-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis...

... Meiosis Spindle structure Kinesins are molecular motor proteins that convert the energy released by ATP hydrolysis into mechanical force ( Vale and Milligan, 2000 ). Because of this characteristic feature, kinesins share a common motor domain of ∼350 amino acids (aa), which couples ATP hydrolysis...

... of the ciliate Tetrahymena thermophila . It localizes to meiotic nuclei and is required for chromosome breakage of developing somatic chromosomes. Ciliate Genome rearrangements DEAD-box RNA Helicase p68 Chromosome Meiosis Like all ciliated protozoans, Tetrahymena thermophila contains two...

... meiosis in synchrony, we were unable to observe meiotic entry in human ‘adrenal’ germ cells until W22. By contrast, ‘ovarian’ germ cells at W22 showed a pronounced asynchronous meiotic entry. Interestingly, we observed that immature POU5F1+ germ cells in both first and second trimester ovaries still...

...Jessica Patel; Seang Lin Tan; Geraldine M. Hartshorne; Andrew D. McAinsh ABSTRACT The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies. A successful meiosis I (MI) division entails separation...

...Tyler J. Broering; Yuan-Liang Wang; Ram Naresh Pandey; Rashmi S. Hegde; Shao-Chun Wang; Satoshi H. Namekawa ABSTRACT Meiosis is precisely regulated by the factors involved in DNA damage response in somatic cells. Among them, phosphorylation of H2AX on Serine 139 (γH2AX) is an essential signal...

..., and by five hours more than half of the paired cells had at least one cell missing a micronucleus. After reversing the colchicine block, existing micronuclei did not undergo elongation again, nor did meiosis occur. These observations indicate that micronuclear elongation is critical to subsequent meiotic...

... in the phosphorylation and degradation of the meiotic cohesion, Rec8, resulting in a failure to proceed through the MII division. These defects are more pronounced in a haploid meiosis model than in a normal diploid meiosis. Thus, several critical meiotic functions are linked specifically to the C-terminus of Dfp1...

... to defects in the assembly of the acentrosomal female Meiosis I spindle that are more severe than those seen in Augmin or γ-TuRC mutants, indicating that Dgp71WD has additional functions that are independent of these complexes in oocytes. Moreover, the localisation of bicoid RNA during oogenesis, which...