...Hope D. Welhaven; Carley N. McCutchen; Ronald K. June ABSTRACT Mechanotransduction is a biological phenomenon where mechanical stimuli are converted to biochemical responses. A model system for studying mechanotransduction are the chondrocytes of articular cartilage. Breakdown of this tissue...

... was phosphorylated by 2.4-fold compared to control ( P <0.05). Together, these results indicate that mechanotransductive pathways are active in cardiac fibroblasts, and lead to the activation of cell signaling pathways involved in cardiac remodeling. * Author for correspondence ( [email protected]...

.... , Welch C. , O'Brien E. T. , Hahn K. , Superfine R. , Burridge K. , Tzima E. ( 2012 ). Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr. Biol. 22 , 2087 – 2094 . 10.1016/j.cub.2012.08.051...

.../licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Mechanotransduction Planar cell polarity Endothelium Shear stress Nucleus Most tissues are characterized by coherent cellular polarization...

... the terms of the Creative Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). E-cadherin Vinculin Actomyosin Mechanotransduction Junction formation Cell–cell adhesion Multicellular epithelial tissues line all cavities...