...Yuta Koui; Takako Ideue; Michael Boylan; Matthew J. Anderson; Motomi Osato; Toshio Suda; Tomomasa Yokomizo; Yoh-suke Mukouyama ABSTRACT Recent genetic lineage tracing studies reveal heterogeneous origins of vascular endothelial cells and pericytes in the developing brain vasculature, despite...

... contact inhibition. Importantly, removal of adult luminal cells in vivo via either an inducible Cre/ loxP -Dre/ rox dual-lineage-tracing system or orthotopic trypsin injection led to robust reactivation of basal stem cell activities, which acts independent of androgen. These data illustrate the prostate...

... mainly within dermal perivascular and hair follicle niches. Lineage tracing of adult Prrx1 enh+ cells shows that they remain in their niches and in small numbers over a long period of time. Upon injury however, Prrx1 enh+ cells readily migrate into the wound bed and amplify, on average, 16-fold beyond...