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Keywords: Lapatinib
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Journal Articles

An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway

Zi-Yan Yang, Liu Yang, Chun-Wei Xu, Xiao-Jia Wang, Lei Lei
Journal: Biology Open
Biol Open (2020) 9 (1): bio047662.
https://doi.org/10.1242/bio.047662
Published: 24 January 2020
... ERBB2 overexpression (ERBB2-MT). P780-Y781 ERBB2 conferred significant resistance to lapatinib, as assessed by cell viability and colony counts. Analysis of the cell cycle showed that the P780-Y781 ERBB2 group showed an elevated proportion of cells in S, G2, and M phases compared with WT ERBB2 when...
View article titled, An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to <span class="search-highlight">lapatinib</span> through AKT signaling pathway
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