1-5 of 5
Keywords: Knockout
Close
Sort by
Journal Articles
Biol Open (2023) 12 (9): bio059970.
Published: 25 August 2023
... effective for generating knockout mice in multiple inbred strains. By combining in vitro fertilisation and electroporation, we obtained founders for knockout alleles in eight common inbred strains. Long-read sequencing analysis detected not only intended mutant alleles but also differences in read frequency...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (1): bio057232.
Published: 6 January 2021
... CTDP1 is required for breast cancer growth and proliferation. To explore the physiological function of CTDP1 in a mammalian system, we generated a conditional Ctdp1 knockout mouse model by insertion of loxP sites upstream of exon 3 and downstream of exon 4. Biallelic deletion of Ctdp1 results...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (11): bio046359.
Published: 7 November 2019
... Knockout Young mice Respiratory distress Mucus gel is the first line of defense in the lung. Gel-forming mucins are high-molecular-weight macromolecules that make up the major organic component of mucus. These molecules are heavily O -glycosylated and dimerize through their carboxy-terminal...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2016) 5 (7): 979–986.
Published: 4 July 2016
...). An LDLR knockout rat was generated via zinc-finger nuclease technology, which harbors a 19-basepair deletion in the seventh exon of the ldlr gene. As expected, deletion of the LDLR elevated total cholesterol and total triglyceride in the plasma, and caused a tenfold increase of plasma LDL-C and a fourfold...
Includes: Supplementary data