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Keywords: Invasion
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Journal Articles
Biol Open (2020) 9 (3): bio049478.
Published: 11 March 2020
... significantly reduced. In addition, the FOXF2 expression was negatively related to the miR-96-5p level in OSCC tissues. Furthermore, downregulation of miR-96-5p obviously restrained OSCC cell proliferation, invasion and EMT. We confirmed that miR-96-5p could directly target FOXF2 by luciferase reporter assay...
Journal Articles
Biol Open (2019) 8 (8): bio042937.
Published: 01 August 2019
..., bioinformatic analysis demonstrated that miRNA-138 directly targeted HIF1α. We found that the introduction of pre-miRNA-138 sequences to A375 cells reduced HIF1α mRNA expression and suppressed cell proliferation, migration and invasion. Overexpression of miRNA-138 or inhibition of HIF1α significantly suppressed...
Journal Articles
Biol Open (2018) 7 (1): bio027557.
Published: 17 January 2018
... mechanism in NKTCL remain unclear. We found that GSN overexpression significantly suppressed cell proliferation, colony formation and invasion, and promoted apoptosis of natural killer (NK) cell line YTS. Moreover, the upregulation of GSN significantly decreased the levels of PI3K and p-Akt. Interestingly...
Journal Articles
Biol Open (2017) 6 (8): 1123–1129.
Published: 12 June 2017
... proliferation and invasion in trophoblast cell lines (BeWo and JAR). Small hairpin RNAs targeting Notch2/Notch3 and Notch2/Notch3-overexpression vectors were designed, constructed and transfected into BeWo and JAR cells. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were then...
Journal Articles
Biol Open (2017) 6 (3): 311–316.
Published: 28 November 2016
... postoperative analgesia with high efficacy and low adverse reaction. A recent study has suggested that parecoxib potently enhances immunotherapeutic efficacy of GBM, but its effects on GBM growth, migration and invasion have not previously been studied. In the present study, MTT [3-(4,5-dimethylthiazol-2-yl...
Journal Articles
Biol Open (2016) 5 (10): 1371–1379.
Published: 19 August 2016
... invasion via a mechanism that is independent from ECM synthesis and dependent on α5β1 integrin and levels of the translation initiation ternary complex. In vivo and ex vivo migration (but not proliferation) of melanoblasts is significantly enhanced in transgenic mice which express additional copies of the...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (6): 669–677.
Published: 16 May 2016
... of miR-93 promoted the proliferation, migration and invasion of glioma cells, and that miR-93 was involved in the regulation of cell cycle progression by mediating the protein levels of P21, P27, P53 and Cyclin D1. P21 was further identified as a direct target of miR-93. Knockdown of P21 attenuated...
Journal Articles
Biol Open (2015) 4 (4): 507–514.
Published: 13 March 2015
... role of TRPM7 channels in pancreatic cancer cell invasion using the Matrigel TM -coated transwell assay. In normal pancreas, TRPM7 is expressed at a discernable level in the ductal cells and centroacinar cells and at a relatively high level in the islet endocrine cells. In chronic pancreatitis, pre...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (10): 924–936.
Published: 12 September 2014
...Ariel E. Cariaga-Martínez; Isabel Cortés; Esther García; Vicente Pérez-García; María J. Pajares; Miguel A. Idoate; Javier Redondo-Muñóz; Inés M. Antón; Ana C. Carrera ABSTRACT The acquisition of invasiveness is characteristic of tumor progression. Numerous genetic changes are associated with...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2012) 1 (8): 711–722.
Published: 12 June 2012
...Kevin M. Branch; Daisuke Hoshino; Alissa M. Weaver Summary Invasion and metastasis are aggressive cancer phenotypes that are highly related to the ability of cancer cells to degrade extracellular matrix (ECM). At the cellular level, specialized actin-rich structures called invadopodia mediate focal...
Includes: Multimedia, Supplementary data