... into the mechanisms involved in the induction, maintenance, and resolution of inflammation. To that end, we developed a non-invasive, inducible, and reversible model of systemic inflammation in zebrafish. Using the Gal4-EcR/UAS system activated by the ecdysone analog tebufenozide, we generated transgenic zebrafish...

.... This result is consistent with the fact that A. urinae infections most frequently occur in patients with underlying urinary tract abnormalities or disorders that make them susceptible to bacterial infection. Unlike uropathogens such as E. coli , which cause infection and inflammation both of the bladder...

... Apoptosis Entorhinal cortex Excitotoxicity Glia activation Inflammation Oxidative stress Tau Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in widespread neuropathology throughout the brain, and severe disruption of cognitive and mnemonic function ( Calderon...

... caused by Staphylococcus aureus . Animal model Prosthetic joint infection Biofilm Inflammation Staphylococcus aureus Total knee arthroplasty Currently, more than 4.7 million and 600,000 people in the USA and Australia, respectively, are estimated to be living with a total knee...

...Honggang Wang; Peiyu Zhong; Leilei Sun ABSTRACT The aim of this study was to investigate whether exogenous hydrogen sulfide (H 2 S) could mitigate NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway in L02 cells. L02 cells were stimulated with different...

..., the effect of 15d-PGJ2 seems to be correlated with the existence of PGDS in the genome of the species. Cyclopentenone prostaglandins are produced at the late stage of inflammatory responses to stop the positive feedback loop and prevent sustained inflammation ( Straus et al., 2000 ; Straus and Glass...

... into the wound tissue, involving -Akt, SPAK/JNK, and p38 MAPK which in turn are involved in Rac1 activation. Furthermore, these results augment our understanding of the insulin-regulated wound inflammatory response. Inflammation Wound healing Neutrophils GTPase Rac1 Diabetes Wound healing...

... impairment due to apoptosis of different inner ear structures. Sepsis Hearing loss Inner ear Inflammation Apoptosis A positive CC-3 staining in the Deiter’s cells has been described previously in lethal sepsis mice ( Schmutzhard et al., 2013 ). A new histopathologic alteration in sepsis...

... apoptosis. MCPIP1 is an RNase critical for controlling inflammation-related mRNAs. MCPIP1 interacts with and degrades a set of stem-loop-containing mRNAs (including IL-6 ). Our results demonstrate the involvement of MCPIP1 in the regulation of IER3 mRNA levels. A dual luciferase assay revealed that over...

... and goblet cell hyperplasia, in the absence of airway wall collagen deposition, suggesting ongoing tissue repair concomitant with acute allergic lung inflammation. Thus, this model may be suitable to delineate airway inflammation processes that precede airway remodeling and development of fixed airway...

... in the zebrafish intestine. Reduction of intestinal inflammation by the administration of the IBD therapeutic, 5-aminosalicylic acid, reduced intestinal lymphatic expansion. Zebrafish macrophages express vascular growth factors vegfaa , vegfc and vegfd and chemical ablation of these cells inhibits intestinal...

... monocytic THP-1 cells, and the increase can be abolished by MAPK and NFκB pathway inhibitors. Lp-PLA 2 inhibitor, 1-linoleoyl glycerol attenuates the inflammation induced by apo CIII. In turn, exogenous Lp-PLA 2 expression upregulates apo CIII and the upregulation can be inhibited by 1-linoleoyl glycerol...

... and reproduction in any medium provided that the original work is properly attributed. Crocodilians Inflammation Histology Crocodilian wound healing and tissue regeneration processes are still poorly studied. There are reports of the tail tip and lower jaw having a partial regenerative capacity...

...Jos Van Rijssel; Ilse Timmerman; Floris P. J. Van Alphen; Mark Hoogenboezem; Olexandr Korchynskyi; Dirk Geerts; Judy Geissler; Kris A. Reedquist; Hans W. M. Niessen; Jaap D. Van Buul Summary Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger...