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Keywords: Inflammation
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Journal Articles
Biol Open (2022) 11 (3): bio058559.
Published: 9 March 2022
... into the mechanisms involved in the induction, maintenance, and resolution of inflammation. To that end, we developed a non-invasive, inducible, and reversible model of systemic inflammation in zebrafish. Using the Gal4-EcR/UAS system activated by the ecdysone analog tebufenozide, we generated transgenic zebrafish...
Journal Articles
Biol Open (2021) 10 (8): bio058931.
Published: 13 August 2021
.... This result is consistent with the fact that A. urinae infections most frequently occur in patients with underlying urinary tract abnormalities or disorders that make them susceptible to bacterial infection. Unlike uropathogens such as E. coli , which cause infection and inflammation both of the bladder...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (1): bio056796.
Published: 25 January 2021
... Apoptosis Entorhinal cortex Excitotoxicity Glia activation Inflammation Oxidative stress Tau Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in widespread neuropathology throughout the brain, and severe disruption of cognitive and mnemonic function ( Calderon...
Journal Articles
Biol Open (2019) 8 (9): bio045203.
Published: 18 September 2019
... . J. Bone Joint Surg. Am.   99 , 232 - 238 . 10.2106/JBJS.16.00127 Gabay , C. ( 2006 ). Interleukin-6 and chronic inflammation . Arthritis. Res. Ther.   8 , S3 . 10.1186/ar1917 Gallo , J. , Svoboda , M. , Zapletalova , J. , Proskova , J. and Juranova , J...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (7): bio043653.
Published: 18 July 2019
...Honggang Wang; Peiyu Zhong; Leilei Sun ABSTRACT The aim of this study was to investigate whether exogenous hydrogen sulfide (H 2 S) could mitigate NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway in L02 cells. L02 cells were stimulated with different...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (11): bio035402.
Published: 13 November 2018
... be adapted to design new drugs. 15d-PGJ2 eIF4A Inflammation Prostaglandins Stress granules Translation 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) is an anti-inflammatory and anti-neoplastic prostaglandin. Although 15d-PGJ2 is known as an agonist of peroxisome proliferator-activated...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (1): bio026187.
Published: 17 January 2018
.... These results delineate cell and molecular mechanisms involved in insulin-induced chemotaxis of monocyte/macrophage, cells that are critical for proper healing. Inflammation Wound healing Neutrophils GTPase Rac1 Diabetes To ensure adequate power to detect specific effect, for all cell studies...
Journal Articles
Biol Open (2017) 6 (6): 732–740.
Published: 15 June 2017
... ). Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view . Mediators Inflamm.   2013 , 165974 . 10.1155/2013/165974 Tweedie , D. , Ferguson , R. A. , Fishman , K. , Frankola , K. A. , Van Praag , H. , Holloway , H. W. , Luo , W...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (7): 889–898.
Published: 2 June 2016
... apoptosis. MCPIP1 is an RNase critical for controlling inflammation-related mRNAs. MCPIP1 interacts with and degrades a set of stem-loop-containing mRNAs (including IL-6 ). Our results demonstrate the involvement of MCPIP1 in the regulation of IER3 mRNA levels. A dual luciferase assay revealed that over...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (2): 112–121.
Published: 6 January 2016
... and goblet cell hyperplasia, in the absence of airway wall collagen deposition, suggesting ongoing tissue repair concomitant with acute allergic lung inflammation. Thus, this model may be suitable to delineate airway inflammation processes that precede airway remodeling and development of fixed airway...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (10): 1270–1280.
Published: 14 September 2015
... in the zebrafish intestine. Reduction of intestinal inflammation by the administration of the IBD therapeutic, 5-aminosalicylic acid, reduced intestinal lymphatic expansion. Zebrafish macrophages express vascular growth factors vegfaa , vegfc and vegfd and chemical ablation of these cells inhibits intestinal...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (5): 661–665.
Published: 14 July 2015
... monocytic THP-1 cells, and the increase can be abolished by MAPK and NFκB pathway inhibitors. Lp-PLA 2 inhibitor, 1-linoleoyl glycerol attenuates the inflammation induced by apo CIII. In turn, exogenous Lp-PLA 2 expression upregulates apo CIII and the upregulation can be inhibited by 1-linoleoyl glycerol...
Journal Articles
Biol Open (2013) 2 (11): 1171–1178.
Published: 16 September 2013
... article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Crocodilians Inflammation Histology...
Journal Articles
Biol Open (2013) 2 (6): 569–579.
Published: 16 April 2013
...Jos Van Rijssel; Ilse Timmerman; Floris P. J. Van Alphen; Mark Hoogenboezem; Olexandr Korchynskyi; Dirk Geerts; Judy Geissler; Kris A. Reedquist; Hans W. M. Niessen; Jaap D. Van Buul Summary Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger...
Includes: Multimedia, Supplementary data