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Keywords: Hyperinsulinemia
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Journal Articles

Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients

Naomichi Abe, Sayuka Kato, Takuma Tsuchida, Kanami Sugimoto, Ryuta Saito, Lars Verschuren, Robert Kleemann, Kozo Oka
Journal: Biology Open
Biol Open (2019) 8 (5): bio041251.
https://doi.org/10.1242/bio.041251
Published: 1 May 2019
..., the non-alcoholic fatty liver disease (NAFLD) activity score, fibrosis progression and metabolic abnormalities such as hyperinsulinemia and obesity were more pronounced in ob/ob mice than in C57BL/6J and KK-A y mice. In ob/ob mice fed FFD, the development of hepatic crown-like structures was confirmed...
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Includes: Supplementary data