...Clayton M. Carey; Hailey L. Hollins; Alexis V. Schmid; James A. Gagnon ABSTRACT Adult humans respond to heart injury by forming a permanent scar, yet other vertebrates are capable of robust and complete cardiac regeneration. Despite progress towards characterizing the mechanisms of cardiac...

... and relaxation. Flies chronically exposed to tobacco smoke exhibited an increased heart rate and alterations in the dynamics of the transient increase of intracellular calcium in myocardial cells. These effects were also evident under acute exposure to nicotine of the heart, in a semi-intact preparation...

..., distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Inhibiting mTOR by rapamycin delays pupation, reduced body wall contractions and mouth-hook movements while synaptic transmission appeared normal in larval Drosophila. Synapse Heart...

... were fed a HFD and exercised. The heart dSir2 gene was specifically expressed or knocked down by UAS/hand-Gal4 system. The results showed that either a HFD or dSir2 knockdown remarkably increased cardiac TG level and d FAS expression, reduced heart fractional shortening and diastolic diameter...

... endoderm of the blastocyst, visceral endoderm of the early post-implantation embryo, as well as lateral plate mesoderm, developing heart, liver, lung and gonads. Here, we generate a novel Gata4 targeted allele used to generate both a Gata4 H2B-GFP transcriptional reporter and a Gata4 FLAG fusion protein...

... into the cardiac ECM is critical to the maintenance of heart integrity and functionality and, therefore, to longevity of the animal. The cardiac ECM connects the heart tube with the alary muscles; thus, the ECM contributes to a flexible positioning of the heart within the animal's body. Moreover, the cardiac ECM...

... properties is not well understood. For example, Baf60c ( Smarcd3 ) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart development is not fully understood. We found that constitutive loss of Baf60c leads to embryonic cardiac hypoplasia and pronounced cardiac...

... to 1% and 2% alcohol and observed the morphology of heart and blood vessels during and after exposure to investigate motor function alterations, and damage and recovery to the cardiovascular system. The results showed that alcohol exposure could induce heart deformation, slower heart rate...

... Heart The bioactive lipid mediator sphingosine-1-phosphate (S1P) plays important roles in various types of biological processes including angiogenesis, inflammation and immunity ( Skoura and Hla, 2009 ; Spiegel and Milstien, 2011 ; Hisano et al., 2012 ). In zebrafish, S1P is involved...

...Mireia Vilardell; Sergi Civit; Ralf Herwig Summary Although approximately 50% of Down Syndrome (DS) patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. A recent study...

... the protein phosphatase inhibition are still unknown and the results of most of the previous studies are often conflicting. The aim of the present study was to evaluate the effects of OA on heart clam cells and to analyse its possible mechanisms of action by investigating the signal transduction pathways...

...Junji Itou; Hiroko Kawakami; Tyler Burgoyne; Yasuhiko Kawakami Summary The zebrafish is a widely used model animal to study the regeneration of organs, such as the fin and heart. Their average lifetime is about 3 years, and recent studies have shown that zebrafish exhibit aging-related degeneration...