...Kyriel M. Pineault; Ilea T. Swinehart; Kayla N. Garthus; Edward Ho; Qing Yao; Ernestina Schipani; Kenneth M. Kozloff; Deneen M. Wellik ABSTRACT Hox genes are critical regulators of skeletal development and Hox9 - 13 paralogs, specifically, are necessary for appendicular development along...

...M. Moris-Sanz; A. Estacio-Gómez; E. Sánchez-Herrero; F. J. Díaz-Benjumea ABSTRACT During development, HOX genes play critical roles in the establishment of segmental differences. In the Drosophila central nervous system, these differences are manifested in the number and type of neurons generated...

..., the expression boundaries of Hox genes are established by repression of gap genes, which is subsequently replaced by Polycomb group (PcG) silencing. At present, however, it is not known whether patterning occurs this way in a more ancestral (short germ) mode of embryogenesis, where segments are added gradually...

...Olivier Boucherat; Jamila Chakir; Lucie Jeannotte Summary Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung...