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Keywords: Germ cell loss
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Journal Articles
Biol Open (2018) 7 (1): bio029470.
Published: 17 January 2018
... in vitro . JAK2 and JAK3 activity is increased while germline cysts are breaking down. Inhibition of either JAK2 or JAK3 prevents germline cyst breakdown and primordial follicle formation. We further show that specific suppression of JAK2 delays germ cell loss through the downregulation of p53, but has...
Includes: Supplementary data