...Fatima Batool; Huma Shireen; Muhammad Faizan Malik; Muhammad Abrar; Amir Ali Abbasi ABSTRACT Tissue-specific gene regulation in mammals involves the coordinated binding of multiple transcription factors (TFs). Using the forebrain as a model, we investigated the syntax of TF occupancy to determine...

... ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Multicellularity and cell differentiation Phenotypic plasticity Eco-evo cell biology Gene regulation Modelling...

... is often accomplished by assigning these regions to the nearest gene in the genome. However, this heuristic ignores key features of genome organisation and gene regulation; in that the genome is partitioned into regulatory domains, which at some loci directly coincide with the span of topologically...

... of estrogens in the regulation of ADGRG7 . This article has an associated First Person interview with the first author of the paper. AIS Adhesion G-protein coupled receptor ADGRG7 GPR128 Estrogen Estradiol (E2) Gene regulation Osteoblasts Adolescent idiopathic scoliosis (AIS) is a complex...

..., in many cases modulating the activity of DNA-binding transcription factors ( Chang and Bruneau, 2012 ). For example, histone deacetylases (HDACs) and bromodomain-containing factors have important roles in cardiac gene regulation and remodeling, and have been proposed as potential drug targets ( Anand et...

.... , Kogai , T. , Schultz , J. J. , Mody , K. and Brent , G. A. ( 2012 ). Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation . J. Biol. Chem.   287 , 36499 - 36508 . 10.1074/jbc.M112.344317...

... under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Cnidarian Oncogenic transcription factor Gene regulation...

... that the original work is properly attributed. Cell survival Gene regulation Postmitotic cells Retina Top2b Transcription Retina degeneration Type II DNA topoisomerases (topoisomerase II, Top2) are DNA machines that are capable of catalyzing an ATP-dependent passage of one DNA duplex through...