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Keywords: Gastruloid
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Journal Articles

CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development

Emily A. Bulger, Todd C. McDevitt, Benoit G. Bruneau
Journal: Biology Open
Biol Open (2024) 13 (3): bio060323.
https://doi.org/10.1242/bio.060323
Published: 19 March 2024
... influences the gene regulatory network underlying extraembryonic mesoderm development. By engineering human induced pluripotent stem cells (hiPSCs) consisting of wild-type (WT), heterozygous (CDX2-Het), and homozygous null CDX2 (CDX2-KO) genotypes, differentiating these cells in a 2D gastruloid model...
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Includes: Supplementary data