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Keywords: Forebrain
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Journal Articles

The combinatorial binding syntax of transcription factors in forebrain-specific enhancers

Fatima Batool, Huma Shireen, Muhammad Faizan Malik, Muhammad Abrar, Amir Ali Abbasi
Journal: Biology Open
Biol Open (2025) 14 (2): BIO061751.
https://doi.org/10.1242/bio.061751
Published: 19 February 2025
...Fatima Batool; Huma Shireen; Muhammad Faizan Malik; Muhammad Abrar; Amir Ali Abbasi ABSTRACT Tissue-specific gene regulation in mammals involves the coordinated binding of multiple transcription factors (TFs). Using the forebrain as a model, we investigated the syntax of TF occupancy to determine...
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Includes: Supplementary data
Journal Articles

Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly

David M. McKean, Lee Niswander
Journal: Biology Open
Biol Open (2012) 1 (9): 874–883.
https://doi.org/10.1242/bio.20121982
Published: 9 July 2012
...David M. McKean; Lee Niswander Summary Holoprosencephaly is the most common forebrain defect in humans. We describe two novel mouse mutants that display a holoprosencephaly-like phenotype. Both mutations disrupt genes in the glycerophosphatidyl inositol (GPI) biosynthesis pathway: gonzo disrupts...
View articletitled, Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly
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Includes: Supplementary data