...Uwe Töpfer ABSTRACT The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs...

...Nicola L. Stevenson ABSTRACT The growth and development of healthy tissues is dependent on the construction of a highly specialised extracellular matrix (ECM) to provide support for cell growth and migration and to determine the biomechanical properties of the tissue. These scaffolds are composed...

.... Summary: ECM remodelling plays a role in the maintenance of intestinal stem cells and crypt morphology during development and in the adult mouse gut. Crypt morphology Extracellular matrix Intestinal stem cells Laminin EMBO http://dx.doi.org/10.13039/100004410 1102-2017 KWF...

... the specialised compartments. In addition to apical remodelling, these shape changes also depend on the proper attachment of the basal plasma membrane to the extracellular matrix (ECM). The ECM provides cues to establish apicobasal polarity, and it also transduces forces that allow apical remodelling. However...

...) and flow cytometry assays. The interaction between miR-9-5p and PPARβ was predicted by TargetScan, and then confirmed by dual-luciferase reporter assay. MiR-9-5p expression was downregulated in HS tissues and HS fibroblasts. MiR-9-5p inhibited the levels of extracellular matrix-associated genes (α-SMA...

...Marcus May; Bernd Denecke; Timm Schroeder; Magdalena Götz; Andreas Faissner ABSTRACT Generation of astrocytes during the development of the mammalian spinal cord is poorly understood. Previously, we have shown that the glycoprotein of the extracellular matrix (ECM) tenascin-C (Tnc) modulates...

...Ariane C. Wilmes; Nora Klinke; Barbara Rotstein; Heiko Meyer; Achim Paululat ABSTRACT In Drosophila , formation of the cardiac extracellular matrix (ECM) starts during embryogenesis. Assembly and incorporation of structural proteins such as Collagen IV, Pericardin, and Laminin A, B1, and B2...

... of excessive extracellular matrix (ECM) in response to signals from damaged epithelial and inflammatory cells. Nevertheless, epithelial cells are capable of expressing components of the ECM, cross-linking enzymes that increase its stability and are sensitive to factors involved in the early stages of fibrosis...

...Shinichi Kawano; Takehiro Torisu; Motohiro Esaki; Kumiko Torisu; Yuichi Matsuno; Takanari Kitazono ABSTRACT Adhesion of cells to the extracellular matrix (ECM) via focal adhesions (FAs) is crucial for cell survival, migration, and differentiation. Although the regulation of FAs, including...

...Jiankai Wei; Guilin Wang; Xiang Li; Ping Ren; Haiyan Yu; Bo Dong ABSTRACT The extracellular matrix (ECM) not only provides essential physical scaffolding for cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis. In this study...

...Nicole M. Myer; Kenneth A. Myers ABSTRACT Endothelial cell (EC) branching is critically dependent upon the dynamic nature of the microtubule (MT) cytoskeleton. Extracellular matrix (ECM) mechanosensing is a prominent mechanism by which cytoskeletal reorganization is achieved; yet how ECM-induced...

... protein. We also used defined conditions to systematically investigate the proliferation and migration responses of primary melanocytes on various extracellular matrix (ECM) substrates. Under our culture conditions, mouse melanocytes exhibit doubling times in the range of 10 days, and retain exponential...

... pseudopods . Before primary mesenchyme cells ingressed, embryos developed an area of orbicular cells in the vegetal plate. The cells surrounding the orbicular cells extended pseudopods toward the orbicular cell area in three Temnopleurus species . In T. toreumaticus , the extracellular matrix was well...

...Miao Yu; Yu Liu; Jing Li; Brianna N. Natale; Shuqin Cao; Dongliang Wang; Jeffrey D. Amack; Huaiyu Hu ABSTRACT Mutations in the extracellular matrix protein eyes shut homolog (EYS) cause photoreceptor degeneration in patients with retinitis pigmentosa 25 (RP25). Functions of EYS remain poorly...

... of the initiator methionine tRNA (tRNA i Met ) in stromal fibroblasts has been shown to influence extracellular matrix (ECM) secretion to drive tumour growth and angiogenesis. Here we show that increased tRNA i Met within cancer cells does not influence tumour growth, but drives cell migration and invasion via...

... on the shape and embryonic placement of the node. Our studies suggest that fibronectin regulates the shape of the node by affecting apico-basal polarity of the nodal cells. Taken together, our data indicate that cell–extracellular matrix interactions mediated by integrin α5β1 and fibronectin regulate...

...Richard P. Tucker; John F. Hess; Qizhi Gong; Katrina Garvey; Bradley Shibata; Josephine C. Adams Summary Thrombospondins are multimeric extracellular matrix glycoproteins that play important roles in development, synaptogenesis and wound healing in mammals. We previously identified four putative...