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Keywords: Epigenetics
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Journal Articles
Biol Open (2023) 12 (6): bio059953.
Published: 5 June 2023
... genes. Similar analysis of chromatin states in other tissues would shed light on whether these transitions are a neuron-specific feature, or a hallmark of all differentiated tissues. Chromatin accessibility assays may provide valuable insights into neuronal epigenetic landscapes and can be used...
Journal Articles
Biol Open (2019) 8 (5): bio042754.
Published: 20 May 2019
... to rejuvenate old NPC and expand the progenitor pool. Here, we compared the chromatin landscape of young and old NPC and found common features reflecting their shared lineage but also intrinsic differences in chromatin accessibility and enhancer landscape supporting the view that old NPC are epigenetically...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (5): bio040352.
Published: 13 May 2019
... metaphase I. The advancement of the synaptic process is related to the epigenetic modification histone H3 lysine 27 trimethylation (H3K27m3). The distribution and dynamics patterns of variant γH2AX and recombinase Rad51 during achiasmatic meiosis suggests formation and repair of DNA double-strand breaks...
Journal Articles
Biol Open (2018) 7 (5): bio031245.
Published: 10 May 2018
...Jian Xu; Benjamin L. Kidder ABSTRACT Trophoblast stem (TS) cells derived from the trophectoderm (TE) of mammalian embryos have the ability to self-renew indefinitely or differentiate into fetal lineages of the placenta. Epigenetic control of gene expression plays an instrumental role in dictating...
Journal Articles
Biol Open (2016) 5 (9): 1177–1188.
Published: 26 August 2016
... of planaria. Biased distribution of epigenetic effects in asymmetrically produced parts of a regenerating organism could increase variation and therefore affect the species' evolution. The maintenance and fixing of somatic experiences, encoded via stable biochemical or physiological states, may contribute...
Journal Articles
Biol Open (2015) 4 (11): 1583–1594.
Published: 30 October 2015
... and analysis of nuclear microsatellite loci confirm triploidy and suggest autopolyploidisation as its cause. Global DNA methylation is significantly reduced in marbled crayfish implying the involvement of molecular epigenetic mechanisms in its origination. Morphologically, both crayfish are very similar...
Journal Articles
Biol Open (2015) 4 (11): 1518–1527.
Published: 21 October 2015
...Lama Tarayrah; Yuping Li; Qiang Gan; Xin Chen ABSTRACT Signaling pathways and epigenetic mechanisms have both been shown to play essential roles in regulating stem cell activity. While the role of either mechanism in this regulation is well established in multiple stem cell lineages, how the two...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (2): 212–223.
Published: 23 January 2015
... methylation and histone retention sites have been correlated with protein-coding genes that are critical for preimplantation embryonic development, physiological evidence of an essential role of these epigenetic marks in fertilization and early development remains lacking. Two miRNA clusters consisting...
Includes: Supplementary data