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Keywords: Enhancers
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Journal Articles

The combinatorial binding syntax of transcription factors in forebrain-specific enhancers

Fatima Batool, Huma Shireen, Muhammad Faizan Malik, Muhammad Abrar, Amir Ali Abbasi
Journal: Biology Open
Biol Open (2025) 14 (2): BIO061751.
https://doi.org/10.1242/bio.061751
Published: 19 February 2025
... tissue-specific enhancer regions. We analyzed forebrain-exclusive enhancers from the VISTA Enhancer Browser and a curated set of 23 TFs relevant to forebrain development and disease. Our findings revealed multiple distinct patterns of combinatorial TF binding, with the HES5-FOXP2-GATA3 triad being...
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Includes: Supplementary data
Journal Articles

The importance of considering regulatory domains in genome-wide analyses – the nearest gene is often wrong!

Ellora Hui Zhen Chua, Samen Yasar, Nathan Harmston
Journal: Biology Open
Biol Open (2022) 11 (4): bio059091.
https://doi.org/10.1242/bio.059091
Published: 4 April 2022
... associated domains (TADs), and that genes are regulated by enhancers located throughout these regions, even across intervening genes. In this review, we examine the results from genome-wide studies using chromosome conformation capture technologies and from those dissecting individual gene regulatory domains...
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