...Yuta Koui; Takako Ideue; Michael Boylan; Matthew J. Anderson; Motomi Osato; Toshio Suda; Tomomasa Yokomizo; Yoh-suke Mukouyama ABSTRACT Recent genetic lineage tracing studies reveal heterogeneous origins of vascular endothelial cells and pericytes in the developing brain vasculature, despite...

...Yihong Chen; Liyan Ye; Linbo Guan; Ping Fan; Rui Liu; Hao Liu; Jinxin Chen; Yue Zhu; Xing Wei; Yu Liu; Huai Bai ABSTRACT Electrical stimulation induces significant neovessel formation in vivo . We have shown that electrical stimulation of endothelial cells functions as an important contributor...

... for angiogenesis, by regulating the endosomal recycling traffic of integrin β1. Cullin-3 (CUL3) Integrin Membrane trafficking Endothelial cells Angiogenesis Angiogenesis (the process of new blood vessel growth) is not only essential to deliver oxygen and nutrients and dispose waste in the body...

... angiogenesis is a hallmark for tumor progression and has become a well-investigated target for cancer treatment. Our motivation was to investigate the role of endogenous AJAP1 in endothelial cells, in particular the effect of AJAP1 on cell migration and sprouting angiogenesis. We hypothesized...

... endothelial cells in vitro . Western blotting analysis showed that rMIF treatment induced LC3 conversion and p62 degradation. Inhibition of autophagy with a PI3K inhibitor (3-MA), a ROS scavenger (NAC) or autophagosomal-lysosomal fusion inhibitors (bafilomycin A1 and chloroquine) rescued rMIF-induced vascular...

... stress fibres and cell rounding in multiple cell types, whereas responses to Rnd2 are more variable. Here we report the responses of endothelial cells to Rnd proteins. Rnd3 induces a very transient decrease in stress fibres but subsequently stimulates a strong increase in stress fibres, in contrast...