... understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor (VEGF) family bind membrane-bound receptor tyrosine kinases (VEGFRs), which trigger multiple signal transduction pathways and diverse cellular responses. We evaluated whether the MAP3K...

... defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) regulate signal transduction and angiogenesis, but how signaling and proteolysis is regulated is not well understood. Here, we provide evidence that a pathway requiring the E1 ubiquitin...

... cardiomyocytes. More recently it has become apparent that non-cardiomyocyte cells of the heart can potentially contribute to cardiotoxicity. Herceptin and doxorubicin are known to induce cardiotoxicity in the clinic. The effect of these drugs on the endothelial tight junction barrier was tested by analysing...

...Gareth W. Fearnley; Gina A. Smith; Izma Abdul-Zani; Nadira Yuldasheva; Nadeem A. Mughal; Shervanthi Homer-Vanniasinkam; Mark T. Kearney; Ian C. Zachary; Darren C. Tomlinson; Michael A. Harrison; Stephen B. Wheatcroft; Sreenivasan Ponnambalam ABSTRACT Vascular endothelial growth factor A (VEGF...

...Gareth W. Fearnley; Alexander F. Bruns; Stephen B. Wheatcroft; Sreenivasan Ponnambalam Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist...

... including the regulation of cell proliferation, migration, differentiation, and survival. It is currently being actively targeted therapeutically using different approaches. We have used human endothelial cells as a model system to compare the effects of inhibiting FAK through several different approaches...