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Keywords: Embryonic stem cells
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Journal Articles
Biol Open (2021) 10 (11): bio058669.
Published: 29 November 2021
...Yao Xiao; Froylan Sosa; Pablo J. Ross; Kenneth E. Diffenderfer; Peter J. Hansen ABSTRACT Bovine embryonic stem cells (ESC) have features associated with the primed pluripotent state including low expression of one of the core pluripotency transcription factors, NANOG. It has been reported...
Journal Articles
Biol Open (2021) 10 (7): bio058544.
Published: 14 July 2021
....00472.2019 Chowdhury , F. , Li , Y. , Poh , Y.-C. , Yokohama-Tamaki , T. , Wang , N. and Tanaka , T. S. ( 2010 ). Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions . PLoS ONE 5 , e15655 . 10.1371...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (6): 850–861.
Published: 08 May 2017
... of Akt isoforms (Akt1, Akt2, and Akt3) in pluripotent stem cell maintenance are not fully defined. Using mouse embryonic stem cells (ESCs), we show that direct inhibition of Akt activity leads to ESC apoptosis. The Akt3, but not Akt1 or Akt2, activity specifically regulates this effect. Inhibiting Akt3...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (4): 511–517.
Published: 13 March 2017
...Shoudong Ye; Tao Zhang; Chang Tong; Xingliang Zhou; Kan He; Qian Ban; Dahai Liu; Qi-Long Ying ABSTRACT Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (12): 1821–1833.
Published: 28 October 2016
..., however the early molecular response to RA signaling is poorly defined, as is its relationship to NMP biology. As endogenous RA is first seen near the time when NMPs appear, we used WNT/FGF agonists to differentiate embryonic stem cells to NMPs which were then treated with a short 2-h pulse of 25 nM RA...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (7): 648–657.
Published: 23 May 2012
... abrogated leading to the rapid death of the mice. Lack of OMCG1 in embryonic stem cells led to a similar cellular phenotype, with multiple mitotic defects and rapid cell death. We showed that mutant intestinal progenitors and embryonic stem cells exhibited a reduced cell cycle arrest following irradiation...
Includes: Multimedia, Supplementary data