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Keywords: ERBB2
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Journal Articles

An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway

Zi-Yan Yang, Liu Yang, Chun-Wei Xu, Xiao-Jia Wang, Lei Lei
Journal: Biology Open
Biol Open (2020) 9 (1): bio047662.
https://doi.org/10.1242/bio.047662
Published: 24 January 2020
...Zi-Yan Yang; Liu Yang; Chun-Wei Xu; Xiao-Jia Wang; Lei Lei ABSTRACT In clinical practice, some breast cancer (BC) patients carry a rare ERBB2 in-frame insertion (p. Pro780_Tyr781insGlySerPro) and are resistant to anti-ERBB2 therapy. To explore the potential procarcinogenic role of this ERBB2...
View article titled, An insertion mutation of <span class="search-highlight">ERBB2</span> enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway
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Journal Articles

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 + breast cancer cells

Carolina D'Alesio, Grazia Bellese, Maria Cristina Gagliani, Anastasia Lechiara, Martina Dameri, Elena Grasselli, Luisa Lanfrancone, Katia Cortese, Patrizio Castagnola
Journal: Biology Open
Biol Open (2019) 8 (4): bio038323.
https://doi.org/10.1242/bio.038323
Published: 18 April 2019
... been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20–30% of BC in which its overexpression leads to increased chemoresistance. Here we investigated whether CHD4 depletion affects the ERBB2 cascade and autophagy, which...
View article titled, The chromodomain helicase CHD4 regulates <span class="search-highlight">ERBB2</span> signaling pathway and autophagy in <span class="search-highlight">ERBB2</span> + breast cancer cells
Open the PDF for The chromodomain helicase CHD4 regulates <span class="search-highlight">ERBB2</span> signaling pathway and autophagy in <span class="search-highlight">ERBB2</span> + breast cancer cells in another window
Includes: Supplementary data