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Keywords: ERBB2
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Journal Articles

An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway

Zi-Yan Yang, Liu Yang, Chun-Wei Xu, Xiao-Jia Wang, Lei Lei
Journal: Biology Open
Biol Open (2020) 9 (1): bio047662.
https://doi.org/10.1242/bio.047662
Published: 24 January 2020
...Zi-Yan Yang; Liu Yang; Chun-Wei Xu; Xiao-Jia Wang; Lei Lei ABSTRACT In clinical practice, some breast cancer (BC) patients carry a rare ERBB2 in-frame insertion (p. Pro780_Tyr781insGlySerPro) and are resistant to anti-ERBB2 therapy. To explore the potential procarcinogenic role of this ERBB2...
View articletitled, An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway
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Journal Articles

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 + breast cancer cells

Carolina D'Alesio, Grazia Bellese, Maria Cristina Gagliani, Anastasia Lechiara, Martina Dameri, Elena Grasselli, Luisa Lanfrancone, Katia Cortese, Patrizio Castagnola
Journal: Biology Open
Biol Open (2019) 8 (4): bio038323.
https://doi.org/10.1242/bio.038323
Published: 18 April 2019
... been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20–30% of BC in which its overexpression leads to increased chemoresistance. Here we investigated whether CHD4 depletion affects the ERBB2 cascade and autophagy, which...
View articletitled, The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 + breast cancer cells
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Includes: Supplementary data