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Keywords: EGFR
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Journal Articles
Biol Open (2019) 8 (3): bio039842.
Published: 5 March 2019
... receptor (Egfr) signaling within the ECs, following secretion of its ligands from the GCs. We show that the conserved family of irre cell recognition module (IRM) proteins is essential for GC encapsulation by ECs, with a requirement for roughest ( rst ) and kin of irre ( kirre ) in the germline...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (8): 1174–1179.
Published: 27 June 2017
... (AREG) secretion. Furthermore, we show that genetic disruption of AREG ameliorates skin pathology in mice carrying the human tylosis disease mutation. Collectively, our data suggest that RHBDF2 plays a critical role in regulating EGFR signaling and its downstream events, including development of tylosis...