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Keywords: EB1
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Journal Articles
Biol Open (2019) 8 (1): bio038620.
Published: 29 January 2019
... with altered microtubule dynamics and stability. In addition, F265L mutation produces a highly specific mitotic spindle positioning defect related to Bim1 (yeast EB1) dysfunction. Indeed, F265L cells display an abnormal Bim1 recruitment profile at microtubule plus-ends. These results indicate that the F265L β...
Journal Articles
Biol Open (2014) 3 (7): 561–570.
Published: 6 June 2014
... growth rates in oocyte spindles, but, unexpectedly, EB1 binding and unbinding are slowed, suggesting a previously unobserved role for kinesin-13 in mediating EB1 binding interactions with microtubules. Kinesin-13 may regulate spindle length both by disassembling subunits from microtubule ends...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (2): 238–250.
Published: 18 December 2012
.... The microtubule growing plus-ends are stabilized by plus-end tracking proteins (+TIPs), mainly EB1 and associated proteins. Myomegalin was identified as a centrosome/Golgi protein associated with cyclic nucleotide phosphodiesterase. We show here that Myomegalin exists as several isoforms. We characterize two...
Includes: Supplementary data