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Keywords: Drosophila
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Journal Articles
Biol Open bio.058809.
Published: 30 July 2021
... survival of the organism. Drosophila hematopoiesis serves as a model system for sensing stress and environmental changes; however, their response to DNA damage remains largely unexplored. The Drosophila lymph gland is the larval hematopoietic organ, where stem-like progenitors proliferate and differentiate...
Journal Articles
Biol Open bio.058531.
Published: 07 July 2021
... such as transmembrane receptors and transport proteins. These are required for the assembly of the cilium, its function as a sensory and signalling centre and to maintain its distinctive composition. Certain motile cilia can also form within the cytosol as exemplified by human and Drosophila sperm. The...
Journal Articles
Biol Open (2021) 10 (2): bio055004.
Published: 15 February 2021
.... However, the homology of certain genes has allowed extrapolation of certain knowledge obtained in animals. Drosophila melanogaster , studied for decades, has been widely used as model for human diseases as well as to study responses associated with the consumption of several substances. In the present...
Journal Articles
Biol Open (2021) 10 (2): bio055640.
Published: 03 February 2021
... Rho-kinase, which results in the localized activation of non-muscle myosin II. Because the Shroom-Rock-myosin II module is conserved in most animal model systems, we have utilized Drosophila melanogaster to further investigate the pathways and components that are required for Shroom to define cell...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (1): bio055996.
Published: 25 January 2021
...Rose Besen-McNally; Kayla J. Gjelsvik; Vicki P. Losick ABSTRACT A key step in tissue repair is to replace lost or damaged cells. This occurs via two strategies: restoring cell number through proliferation or increasing cell size through polyploidization. Studies in Drosophila and vertebrates have...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (12): bio054262.
Published: 03 December 2020
... cells in culture, the contributions of MICOS to tissue homeostasis in vivo remain further elucidation. In this study, we examined how knocking down expression of Drosophila MICOS genes affects mitochondrial function and muscle tissue homeostasis. We found that CG5903/MIC26-MIC27 colocalizes and...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (10): bio054452.
Published: 08 October 2020
...Evgenia K. Karpova; Evgenii G. Komyshev; Mikhail A. Genaev; Natalya V. Adonyeva; Dmitry A. Afonnikov; Margarita A. Eremina; Nataly E. Gruntenko ABSTRACT A method for automation of imago quantifying and fecundity assessment in Drosophila with the use of mobile devices running Android operating...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (9): bio054361.
Published: 16 September 2020
... Drosophila community resource for investigating the mechanisms of sleep regulation. Our data show that flies with short-sleep periods have ∼16% longer life span, as well as reduced aging rate, compared to flies with long-sleep. In contrast, disrupting normal circadian rhythm reduces fly longevity. Short...
Journal Articles
Biol Open (2020) 9 (8): bio053421.
Published: 25 August 2020
... Drosophila and examined the impact on the larval neuromuscular junction (NMJ). Surprisingly, we show that both null mutants and MN-specific knockdown of Vps54 leads to NMJ overgrowth. Reduction of Vps54 partially disrupts localization of the t-SNARE, Syntaxin-16, to the TGN but has no visible impact on...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (8): bio053629.
Published: 18 August 2020
... the larval brain of Drosophila . The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that is observed throughout development between the central brain and the optic lobe. Neural stem cells in both compartments show the...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (6): bio052241.
Published: 14 June 2020
... (Acacia/Senegal gum), a widely used stabilizer, can also emulsify lipophilic compounds and profoundly increase their accessibility to target tissues in Drosophila and mice. We further developed a gum Arabic-based drug delivery system, wherein the drug was ground into gum Arabic and emulsified in liquid...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (4): bio046565.
Published: 13 April 2020
... stem cells, but not others, show lethality due to failures in ribosome biogenesis or function (now known as nucleolar stress). To determine if various Drosophila neuroblasts display differential sensitivities to nucleolar stress, we used CRISPR-Cas9 to disrupt the Nopp140 gene that encodes two splice...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (3): bio049999.
Published: 11 March 2020
... physiology remains poorly understood. We therefore analyzed heart-specific SOCE function in Drosophila , a powerful animal model of cardiac physiology. We show that heart-specific suppression of Stim and Orai in larvae and adults resulted in reduced contractility consistent with dilated cardiomyopathy...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (1): bio047530.
Published: 14 January 2020
... we explored the consequences of increasing contacts between mitochondria and the ER in flies using a synthetic linker. We showed that enhancing MERCs increases locomotion and extends lifespan. We also showed that, in a Drosophila model of Alzheimer's disease linked to toxic amyloid beta (Aβ), linker...
Journal Articles
Biol Open (2020) 9 (1): bio047043.
Published: 13 January 2020
...Eri Arimoto; Yutaro Kawashima; Taein Choi; Mami Unagami; Shintaro Akiyama; Mizuki Tomizawa; Hiroyuki Yano; Emiko Suzuki; Masaki Sone ABSTRACT We previously identified the Drosophila yata mutant, which showed phenotypes including progressive vacuolization of the white-coloured compound eye...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (12): bio047233.
Published: 02 January 2020
...Anand K. Singh; Akilu Abdullahi; Matthias Soller; Alexandre David; Saverio Brogna ABSTRACT The distribution of assembled, and potentially translating, ribosomes within cells can be visualised in Drosophila by using Bimolecular Fluorescence Complementation (BiFC) to monitor the interaction between...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (12): bio046524.
Published: 20 December 2019
... that endoplasmic reticulum (ER) stress accumulation in insulin-producing cells (IPCs) generated diabetes-like phenotypes in Drosophila . To promote the accumulation of extra ER stress, we induced a dominant-negative form of a Drosophila ER chaperone protein (Hsc70-3 DN ) and demonstrate that it causes...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (11): bio046789.
Published: 12 November 2019
... generation RNA sequencing (RNA-seq) the transcriptome of germline stem cell (GSC)-like cells isolated from bag of marbles ( bam ) mutant Drosophila ovaries and compared it to the transcriptome of germ line cells isolated from wild-type ovaries. We have complemented this dataset by utilizing an RNA...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (10): bio047126.
Published: 18 October 2019
... Commons Attribution License ( https://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Heparan sulfate chains in Drosophila adult intestinal stem cells negatively...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (10): bio046961.
Published: 15 October 2019
... during development and aging of the Drosophila model system. Hence, through engagement of the GAL4/UAS genetic platform and RNAi technology, we herein examined the in vivo significance of Atox1 and CCS genes, products of which pivotally govern cellular copper trafficking in fly tissue pathophysiology...
Includes: Supplementary data