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Keywords: Driver mutation
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Journal Articles
Biol Open (2016) 5 (5): 645–653.
Published: 22 April 2016
... T-ALL development and prevents Notch1 deletions, while allowing for transient hematopoietic stem cell (HSC)-like pre-leukemia cell expansion. Together, our data suggest that PRDM14 expands a progenitor cell population while promoting a permissive epigenetic state for the creation of driver mutations...
Includes: Supplementary data