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Journal: Biology Open
Biol Open (2017) 6 (2): 176–186.
Published: 23 December 2016
...Taylor E. Miller; Julian Gomez-Cambronero ABSTRACT The removal of mRNA transcript poly(A) tails by 3′→5′ exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological...