..., DNA replication inhibition strongly reduced EdU + cell numbers and caused molting-related fatalities. Our study is the first to demonstrate using molecular approaches that storage cells actively proliferate during tardigrade post-embryonic development, providing a comprehensive insight...

... checkpoint defect occurs only when DNA replication forks break in cells without the intra-S phase checkpoint kinase Cds1. Chk1-S173A is also unable to block mitosis when the G1 transcription factor Cdc10 ( cdc10.V50 ) is impaired. We conclude that serine 173, which is equivalent to lysine 166...

... of the nuclear-matrix­-associated DNA replication protein, CIZ1, extends their window of proliferation during cardiac development, delaying onset of terminal differentiation without compromising function. CIZ1-expressing hearts are enlarged, but the cardiomyocytes are smaller with an overall increase in number...

...Fei Lu; Xiaojun Wu; Feng Yin; Christina Chia-Fang Lee; Min Yu; Ivailo S. Mihaylov; Jiekai Yu; Hong Sun; Hui Zhang ABSTRACT DNA replication licensing occurs on chromatin, but how the chromatin template is regulated for replication remains mostly unclear. Here, we have analyzed the requirement...

.... Summary: This study, using a temperature sensitive mec1 mutant, reveals that inactivation of Mec1 leads to S phase arrest, and that genome duplication in the absence of Mec1/ATR is exquisitely sensitive to small changes in dNTP levels. Mec1 ATR Sml1 RNR dNTP DNA replication Replication...