...Tram Thi Ngoc Nguyen; Jiwon Shim; Young-Han Song ABSTRACT Ionizing radiation (IR) induces DNA double-strand breaks that activate the DNA damage response (DDR), which leads to cell cycle arrest, senescence, or apoptotic cell death. Understanding the DDR of stem cells is critical to tissue...

... strong sperm selection mechanisms and activate a zygotic DNA damage response (DDR) (including cell cycle arrest, DNA repair and alternative apoptosis) in order to guarantee the genomic conformity of the reduced progeny. However, external fertilizers, with different reproductive strategies, seem...

... double KO mice show defects in the DNA damage response caused by T-cell-specific DNA rearrangement-associated double strand breaks, and differentiation into mature T cells was blocked ( Vogel et al., 2016 ). Vogel et al. (2016) speculated that the function of ZFP36L1/ZFP36L2 is suppressed by an ‘as-yet...