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Keywords: Cofilin
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Journal Articles

Protein complexes from mouse and chick brain that interact with phospho-KXGS motif tau/microtubule associated protein antibody

D. S. Davies, A. T. Arthur, H. L. Aitken, B. Crossett, C. S. Goldsbury
Journal: Biology Open
Biol Open (2024) 13 (2): bio060067.
https://doi.org/10.1242/bio.060067
Published: 27 February 2024
... during normal embryonic development (mammals and birds) and at the early stages of human Alzheimer’s disease (AD). It also labels ADF/cofilin-actin rods that form in neurites during exposure to stressors. We aimed to identify direct and indirect 12E8 binding proteins in postnatal mouse brain...
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Includes: Supplementary data
Journal Articles

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway

Dejiang Pang, Chengcheng Yang, Chao Li, Yuanfeng Zou, Bin Feng, Lixia Li, Wentao Liu, Qihui Luo, Zhengli Chen, Chao Huang
Journal: Biology Open
Biol Open (2020) 9 (2): bio046854.
https://doi.org/10.1242/bio.046854
Published: 7 February 2020
... cells. In addition, we have found that PP2-mediated cofilin activity suppression was implicated in the inhibition of liver cancer cell motility. Decreased expression of two major hydrolytic enzymes (MMP2/MMP9), through the AKT/NF-κB signaling pathway may also be also responsible for this process. Rescue...
View articletitled, Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
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