... of TI, we thus examine the effects of silibinin on TI-induced FAT10 expression and CIN. Our data showed that silibinin inhibited expression of FAT10, TI-induced chromosome instability (CIN) as well as sensitizes cells to TI-induced apoptosis. Significantly, silibinin suppressed intra-tumorally injected...

.... DNA damage KDM4 proteins Mismatch repair Chromosomal instability Lysine demethylation A decade ago, two families of lysine demethylases (KDM) have been identified, confirming that lysine methylation is a reversible and dynamically regulated process ( Klose et al., 2006a ; Shi et al., 2004...