... that NuRD coordinates gene expression changes, which acts to maintain a barrier between different stable states. Thus NuRD-mediated chromatin remodelling serves multiple functions, including reducing transcriptional noise, priming genes for activation and coordinating the transcriptional response...

.... The vast majority of these DNMs are heterozygous loss-of-function mutations with high penetrance for autism. CHD8 is a chromatin remodeler that preferentially regulates expression of genes implicated in early development of the cerebral cortex. How CHD8 haploinsufficiency alters the normal developmental...

...Marta Portela; Daniel Jimenez-Carretero; Veronica Labrador; Maria Jose Andreu; Elvira Arza; Valeria R. Caiolfa; Miguel Manzanares ABSTRACT Most studies addressing chromatin behaviour during preimplantation development are based on biochemical assays that lack spatial and cell-specific information...

... was either not coupled with biotin (Ctl) or EdU-labelled cells were submitted to a thymidine chase in order to compare replication fork versus fork-free chromatin ( Fig. 5 A). As shown in Fig. 5 B and C, KDM5A was specifically enriched at on-going replication forks when compared to the thymidine chase...

...Mei-Zi Zhang; Xiao-Min Cao; Feng-Qin Xu; Xiao-Wei Liang; Long-Long Fu; Bao Li; Wei-Guang Liu; Shuo-Guo Li; Fang-Zhen Sun; Xiu-Ying Huang; Wei-Hong Huang ABSTRACT In human sperm, a fraction of its chromatin retains nucleosomes that are positioned on specific sequences containing genes and regulatory...

... and positioning of organelles. One of the major findings was the anisotropic and subtype-specific growth of the different PRC compartments. In addition, a transient accumulation of endoplasmic reticulum in rod PRCs, changes in chromatin organisation in UV sensitive cones and differential expression of polarity...

... these cell types. In particular, ES cells contain bivalent chromatin domains consisting of the activating H3K4me3 and repressive H3K27me3 histone modifications, which are enriched at developmental genes that are repressed in ES cells but active during differentiation. However, H3K4me3/H3K27me3 bivalent...

...Alice Sherrard; Paul Bishop; Melanie Panagi; Maria Beatriz Villagomez; Dominic Alibhai; Abderrahmane Kaidi ABSTRACT Changes in chromatin structure are key determinants of genomic responses. Thus, methods that enable such measurements are instrumental for investigating genome regulation and function...

... Memory Inheritance Epigenetics Evolution Generations Transgenerational Small RNAs Chromatin Most models of evolution, which are based on Mendelian genetics, depend conceptually on the existence of a distinct separation between generations across an ancestry. This distinction between...

...Thomas W. Flanagan; Jacob K. Files; Kelsey Rose Casano; Eric M. George; David T. Brown ABSTRACT Mammals express six major somatic linker histone subtypes, all of which display dynamic binding to chromatin, characterized by transient binding at a given location followed by rapid translocation...

... ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. ATRX Cell division Chromatin Cortical lamination Neurodevelopment The ATRX protein belongs to a family...

... with gene transcription in animals and plants. In animals, H3.3 is deposited into chromatin by specific protein complexes, including the HIRA complex. H3.3 variants evolved independently and acquired similar properties in animals and plants, questioning how the H3.3 deposition machinery evolved in plants...

... of the Creative Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Stem cells NuRD DNA methylation Trophectoderm Chromatin The first lineage commitment event during early mammalian development results in the segregation of two distinct...