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Keywords: Chk1
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Journal Articles

The kinase domain residue serine 173 of S chizosaccharomyce s pombe Chk1 kinase is critical for the response to DNA replication stress

Open Access
Naomi Coulton, Thomas Caspari
Journal: Biology Open
Biol Open (2017) 6 (12): 1840–1850.
https://doi.org/10.1242/bio.029272
Published: 1 November 2017
...Naomi Coulton; Thomas Caspari ABSTRACT While mammalian Chk1 kinase regulates replication origins, safeguards fork integrity and promotes fork progression, yeast Chk1 acts only in G1 and G2. We report here that the mutation of serine 173 (S173A) in the kinase domain of fission yeast Chk1 abolishes...
View articletitled, The kinase domain residue serine 173 of S chizosaccharomyce s pombe Chk1 kinase is critical for the response to DNA replication stress
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Includes: Supplementary data