...Krystal Timón Pérez; Jacopo Scrofani; Isabelle Vernos ABSTRACT During mitosis, spindle assembly relies on centrosomal and acentrosomal microtubule nucleation pathways that all require the γ-Tubulin Ring Complex (γ-TuRC) and its adaptor protein NEDD1. The activity of these different pathways needs...

... their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the cohesion of duplicated centrosomes in dividing cells. We show here that regulators of the LRRK2 signaling pathway including vps35 and PPM1H...

... of the SubcellularDistribution pipeline, we examined the subcellular distribution of mRNA relative to centrosomes within syncytial Drosophila embryos. Centrosomes are microtubule-organizing centers, and RNA enrichments at centrosomes are of emerging importance. Our open-source and freely available software detected RNA...

... disease. Aggresomes are closely-related, cellular accumulations of misfolded proteins. They develop in a juxtanuclear position, adjacent to the centrosome, the microtubule organizing centre of the cell, and share some protein components. Despite the long-standing observation that aggresomes/Lewy bodies...

...Rustem Uzbekov; Anastasiia Garanina; Christophe Bressac ABSTRACT The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles...

...Stephen J. Enos; Martin Dressler; Beatriz Ferreira Gomes; Anthony A. Hyman; Jeffrey B. Woodruff ABSTRACT Centrosomes are microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass...

... may homo-multimerise in multiple ways, and that their interaction is likely complex and may differ between species. Centriole duplication Centrosome Cartwheel Centrioles form centrosomes and cilia, two organelles that have many important functions ( Bettencourt-Dias et al., 2011...

...Jeffrey C. Medley; Megan M. Kabara; Michael D. Stubenvoll; Lauren E. DeMeyer; Mi Hye Song ABSTRACT Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing bipolar mitotic...

...Oliver Wueseke; David Zwicker; Anne Schwager; Yao Liang Wong; Karen Oegema; Frank Jülicher; Anthony A. Hyman; Jeffrey B. Woodruff ABSTRACT Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material...

...Michelle Kowanda; Julie Bergalet; Michal Wieczorek; Gary Brouhard; Éric Lécuyer; Paul Lasko ABSTRACT The centrosome-associated proteins Ninein (Nin) and Ninein-like protein (Nlp) play significant roles in microtubule stability, nucleation and anchoring at the centrosome in mammalian cells. Here, we...

...Jennifer H. Richens; Teresa P. Barros; Eliana P. Lucas; Nina Peel; David Miguel Susano Pinto; Alan Wainman; Jordan W. Raff ABSTRACT Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic...

..., the number of immature and mature follicles increased in the hmmr +/+ ovaries while decreasing (up to 100-fold) in hmmr m/m ones ( Fig. 4H ). Fig. 4. The RHAMM centrosome-targeting domain is required for adult ovarian folliculogenesis. Visualization (A–F) and quantification (G,H) of ovarian...

... duplication Phosphorylation Centrosome Centrosomes organize the microtubule cytoskeleton and are essential for the assembly of cilia in animal cells ( Brito et al., 2012 ). They participate in mitotic spindle formation and thereby ensure faithful chromosome segregation during cell division. One...

... ). Mechanosensory-defective, male-sterile unc mutants identify a novel basal body protein required for ciliogenesis in Drosophila. Development 131 , 3411 – 3422 . 10.1242/dev.01229 Balczon R. , Varden C. E. , Schroer T. A. ( 1999 ). Role for microtubules in centrosome doubling...

...Jianqiu Zou; Fen Tian; Ji Li; Wyatt Pickner; Molly Long; Khosrow Rezvani; Hongmin Wang; Dong Zhang Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two...

... and continuous production of neurons. The Pax6 transcription factor plays a major role in INM by regulating various downstream molecules. We have previously observed abnormal INM and unstable localization of the centrosome in APs of the Pax6 homozygous mutant rat embryo. To understand the mechanisms of INM, we...

... Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Centriolar satellites Centrosome Distal appendages Primary cilium The centrosome performs many functions in the cell including: acting as a microtubule organizing centre (MTOC), establishing cell polarity...

...Régine Roubin; Claire Acquaviva; Véronique Chevrier; Fatima Sedjaï; Déborah Zyss; Daniel Birnbaum; Olivier Rosnet Summary The generation of cellular microtubules is initiated at specific sites such as the centrosome and the Golgi apparatus that contain nucleation complexes rich in γ-tubulin...

... Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). C. elegans Centrosome Microtubules Mitotic spindle assembly PP2A Protein phosphatase Proteomics studies suggest that changes in protein phosphorylation are particularly...

...Meredith Leo; Diana Santino; Irina Tikhonenko; Valentin Magidson; Alexey Khodjakov; Michael P. Koonce Summary The assembly of a functional mitotic spindle is essential for cell reproduction and requires a precise coordination between the nuclear cycle and the centrosome. This coordination...