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Keywords: Centrosome
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Journal Articles
Biol Open (2022) 11 (8): bio059468.
Published: 29 July 2022
... their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the cohesion of duplicated centrosomes in dividing cells. We show here that regulators of the LRRK2 signaling pathway including vps35 and PPM1H...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (10): bio055228.
Published: 19 October 2020
... of the SubcellularDistribution pipeline, we examined the subcellular distribution of mRNA relative to centrosomes within syncytial Drosophila embryos. Centrosomes are microtubule-organizing centers, and RNA enrichments at centrosomes are of emerging importance. Our open-source and freely available software detected RNA...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (10): bio054338.
Published: 5 October 2020
... disease. Aggresomes are closely-related, cellular accumulations of misfolded proteins. They develop in a juxtanuclear position, adjacent to the centrosome, the microtubule organizing centre of the cell, and share some protein components. Despite the long-standing observation that aggresomes/Lewy bodies...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (8): bio036012.
Published: 15 August 2018
...Rustem Uzbekov; Anastasiia Garanina; Christophe Bressac ABSTRACT The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (1): bio029777.
Published: 12 January 2018
...Stephen J. Enos; Martin Dressler; Beatriz Ferreira Gomes; Anthony A. Hyman; Jeffrey B. Woodruff ABSTRACT Centrosomes are microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (3): 381–389.
Published: 15 February 2017
... may homo-multimerise in multiple ways, and that their interaction is likely complex and may differ between species. Centriole duplication Centrosome Cartwheel Centrioles form centrosomes and cilia, two organelles that have many important functions ( Bettencourt-Dias et al., 2011...
Journal Articles
Biol Open (2017) 6 (1): 17–28.
Published: 23 November 2016
...Jeffrey C. Medley; Megan M. Kabara; Michael D. Stubenvoll; Lauren E. DeMeyer; Mi Hye Song ABSTRACT Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing bipolar mitotic...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (10): 1431–1440.
Published: 2 September 2016
...Oliver Wueseke; David Zwicker; Anne Schwager; Yao Liang Wong; Karen Oegema; Frank Jülicher; Anthony A. Hyman; Jeffrey B. Woodruff ABSTRACT Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (8): 1040–1051.
Published: 15 July 2016
...Michelle Kowanda; Julie Bergalet; Michal Wieczorek; Gary Brouhard; Éric Lécuyer; Paul Lasko ABSTRACT The centrosome-associated proteins Ninein (Nin) and Ninein-like protein (Nlp) play significant roles in microtubule stability, nucleation and anchoring at the centrosome in mammalian cells. Here, we...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (8): 1052–1061.
Published: 24 July 2015
...Jennifer H. Richens; Teresa P. Barros; Eliana P. Lucas; Nina Peel; David Miguel Susano Pinto; Alan Wainman; Jordan W. Raff ABSTRACT Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (4): 562–571.
Published: 6 March 2015
...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Gametogenesis Folliculogenesis Hypofertility Spindle RHAMM Oriented mitosis Centrosome The postnatal mammalian ovary contains...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (3): 370–377.
Published: 20 February 2015
...-terminus of Ana2 and STIL has been denoted the STil/ANa2 (STAN) motif ( Stevens et al., 2010a ). Experiments using truncations of the STAN motif have shown that it is required for centrosomal localization and duplication ( Vulprecht et al., 2012 ; Arquint and Nigg, 2014 ). Ohta et al. ( Ohta et al., 2014...
Journal Articles
Biol Open (2013) 2 (11): 1137–1147.
Published: 11 September 2013
... attributed. Drosophila Centriole Centrosome Cilia Spermatocyte Transition zone Primary cilia are essential organelles for animal development and human disease. Cilia are assembled from plasma membrane-tethered basal bodies that project their microtubule-based axonemes from the cell surface...
Journal Articles
Biol Open (2013) 2 (10): 1022–1031.
Published: 6 August 2013
...Jianqiu Zou; Fen Tian; Ji Li; Wyatt Pickner; Molly Long; Khosrow Rezvani; Hongmin Wang; Dong Zhang Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (7): 739–749.
Published: 10 June 2013
... and continuous production of neurons. The Pax6 transcription factor plays a major role in INM by regulating various downstream molecules. We have previously observed abnormal INM and unstable localization of the centrosome in APs of the Pax6 homozygous mutant rat embryo. To understand the mechanisms of INM, we...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (6): 535–545.
Published: 9 April 2013
... Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Centriolar satellites Centrosome Distal appendages Primary cilium During primary ciliogenesis, the distal appendages of the mother centriole are proposed to participate in the anchoring of a ciliary vesicle...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (2): 238–250.
Published: 18 December 2012
...Régine Roubin; Claire Acquaviva; Véronique Chevrier; Fatima Sedjaï; Déborah Zyss; Daniel Birnbaum; Olivier Rosnet Summary The generation of cellular microtubules is initiated at specific sites such as the centrosome and the Golgi apparatus that contain nucleation complexes rich in γ-tubulin...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (1): 88–94.
Published: 13 November 2012
... Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). C. elegans Centrosome Microtubules Mitotic spindle assembly PP2A Protein phosphatase Proteomics studies suggest that changes in protein phosphorylation are particularly...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (11): 1111–1117.
Published: 4 September 2012
...Meredith Leo; Diana Santino; Irina Tikhonenko; Valentin Magidson; Alexey Khodjakov; Michael P. Koonce Summary The assembly of a functional mitotic spindle is essential for cell reproduction and requires a precise coordination between the nuclear cycle and the centrosome. This coordination...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (10): 965–976.
Published: 8 August 2012
...Katharina F. Sonnen; Lothar Schermelleh; Heinrich Leonhardt; Erich A. Nigg Summary Centrioles are essential for the formation of cilia and flagella. They also form the core of the centrosome, which organizes microtubule arrays important for cell shape, polarity, motility and division. Here, we have...
Includes: Supplementary data