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Keywords: Centriole duplication
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Journal Articles

Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

Open Access
Daisuke Takao, Koki Watanabe, Kanako Kuroki, Daiju Kitagawa
Journal: Biology Open
Biol Open (2019) 8 (9): bio047175.
https://doi.org/10.1242/bio.047175
Published: 18 September 2019
...Daisuke Takao; Koki Watanabe; Kanako Kuroki; Daiju Kitagawa ABSTRACT Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell...
View articletitled, Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
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Includes: Supplementary data
Journal Articles

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

Open Access
Matthew A. Cottee, Steven Johnson, Jordan W. Raff, Susan M. Lea
Journal: Biology Open
Biol Open (2017) 6 (3): 381–389.
https://doi.org/10.1242/bio.024661
Published: 15 February 2017
...Matthew A. Cottee; Steven Johnson; Jordan W. Raff; Susan M. Lea ABSTRACT A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly. In humans, this interaction is mediated...
View articletitled, A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies
Open the PDF for A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies in another window
Journal Articles

Plk4-dependent phosphorylation of STIL is required for centriole duplication

Open Access
Anne-Sophie Kratz, Felix Bärenz, Kai T. Richter, Ingrid Hoffmann
Journal: Biology Open
Biol Open (2015) 4 (3): 370–377.
https://doi.org/10.1242/bio.201411023
Published: 20 February 2015
.... Failures in centriole duplication result in abnormal centriole numbers, which have been linked to genomic instability and tumorigenesis. Studies in C. elegans reveal an evolutionary conserved pathway in centriole formation ( Pelletier et al., 2006 ; Delattre et al., 2006 ), and several key...
View articletitled, Plk4-dependent phosphorylation of STIL is required for centriole duplication
Open the PDF for Plk4-dependent phosphorylation of STIL is required for centriole duplication in another window