..., are important for cell migration and are involved in many (patho)-physiological processes. Here we examined FAs and their associated actin fibres using correlative fluorescence and scanning electron microscopy (SEM). We used fluorescence images of cells expressing paxillin-GFP to define the boundaries of FA...

..., thus regulating F-actin levels, through the branched actin regulator WSP-1, and myosin enrichment. RhoGAP RGA-8 thus polarizes epithelia, to promote cell migrations and cell shape changes of embryonic morphogenesis. * Author for correspondence ( sotomc@rutgers.edu ) Competing interests...

... illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy. Bone Cell migration FA turnover Preosteoblast Preosteoblast or their precursors can migrate into bone...

... that these alterations to the dynamics and underlying actin architecture also affect D25c2 cell migration and decrease arborization in Drosophila neurons. We present the hypothesis that Naus functions to slow Cortactin's disassociation from Arp2/3 nucleated branch junctions, thereby increasing both branch nucleation...

... . J. Neurosci.   29 , 10695 - 10705 . 10.1523/JNEUROSCI.2658-09.2009 Chazal , G. , Durbec , P. , Jankovski , A. , Rougon , G. and Cremer , H. ( 2000 ). Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse...

... imaging of Drosophila tracheogenesis revealed elevated Ca 2+ levels in migratory tip cells as they form branches. SERCA blockade abolished this Ca 2+ differential, aborting both cell migration and new branching. Activating protein kinase C (PKC) rescued Ca 2+ in tip cells and restored cell migration...

... is reduced or lost, including hepatocellular and esophageal squamous cell carcinoma, and glial-derived tumors. The aberrant expression of AJAP1 is associated with alterations in cell migration, invasion, increased tumor growth, and tumor vascularization, suggesting AJAP1 as a putative tumor suppressor. We...

... . 10.1016/j.ydbio.2008.02.012 Summary: Using spatial and temporally controlled perturbations followed by live cell tracking in vivo , this paper demonstrates that directional movements downstream of Gbx2 and Otx2 are important for otic and lens placode formation. Cell migration Lens Live...

... of the initiator methionine tRNA (tRNA i Met ) in stromal fibroblasts has been shown to influence extracellular matrix (ECM) secretion to drive tumour growth and angiogenesis. Here we show that increased tRNA i Met within cancer cells does not influence tumour growth, but drives cell migration and invasion via...

... features of both amoeboid and mesenchymal migration modes. Twist1 Dissemination Epithelial-mesenchymal transition Cell migration Intercellular junctions Proteolysis Dissemination, the release of cells and their migration away from epithelial tissues, plays an essential role in both...

...Zhihai Zhao; Song Hui Tan; Hiroaki Machiyama; Keiko Kawauchi; Keigo Araki; Hiroaki Hirata; Yasuhiro Sawada ABSTRACT Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration...

... and differentiation, probably by protecting CXCR4 from degradation. BRE Knockout mice Muscle satellite cells Skeletal muscle regeneration Cell migration Skeletal muscle accounts for approximately 40-50% of the human body's mass and it's the most abundant tissue. The main function of skeletal muscle...

...Gareth W. Fearnley; Alexander F. Bruns; Stephen B. Wheatcroft; Sreenivasan Ponnambalam Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist...

... provided that the original work is properly attributed. Zebrafish MDGA Cranial motoneurons Digital light sheet microscopy Cell migration Cell adhesion Axon guidance During the formation of the nervous system subsets of postmitotic neuroblasts delaminate from primary neuroepithelia...

... provided that the original work is properly attributed. Eph receptors Contact inhibition of locomotion Cell migration Prostate cancer Rho GTPases Vav2 To metastasise, carcinoma cells in primary tumours must first break down their epithelial cell–cell junctions and break away from...

... changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division...

... attributed. Cell culture Cell migration Cytoskeleton dynamics Drosophila Ecdysone Hemocytes One of the most striking changes we observed in vivo at puparium formation was the rapid colonization of the entire body by hemocytes that were previously sessile and attached...

... with leukocyte adhesion deficiency-1: normal displacement in close quarters via chimneying. Cell Motil. Cytoskeleton 46 , 183 – 189 . 10.1002/1097-0169(200007)46:3<183::AID-CM3>3.0.CO;2-2 Molyneaux K. , Wylie C. ( 2004 ). Primordial germ cell migration. Int. J. Dev. Biol. 48...

... protein (GAP) and ADP-ribosyltransferase (ADPRT) enzyme activities, and differences in MTLn3 and MTC cell responsiveness to ExoS were found to relate to the targeting of ExoS-GAP activity to Rho GTPases. MTLn3 cell migration is mediated by RhoA activation at the leading edge, and inhibition of RhoA...

...Yan Li; Xiao-yu Wang; Ting Wu; Manli Chuai; Kenneth Ka Ho Lee; Li-jing Wang; Xuesong Yang Summary PTEN is a tumor suppressor gene that is mutated and/or deleted in many types of tumor. This gene also plays a very distinct role in the early stages of embryonic development such as cell migration...