...Koichi Ojima; Shoji Hata; Fumiko Shinkai-Ouchi; Mika Oe; Susumu Muroya; Hiroyuki Sorimachi; Yasuko Ono ABSTRACT Calpain-3 (CAPN3) is a muscle-specific type of calpain whose protease activity is triggered by Ca 2+ . Here, we developed CAPN3 sensor probes (SPs) to detect activated-CAPN3 using...

... was correlated with increased epidermal growth factor receptor (EGFR) activation, elevated levels of intracellular Ca 2+ , calpain activation and accelerated cleavage of ITGβ4. Activation of EGFR and calpain activity was responsible for a redistribution of ITGβ4 from the basal layer of NPC cells to peripheral...

...Elena Marcassa; Marzia Raimondi; Tahira Anwar; Eeva-Liisa Eskelinen; Michael P. Myers; Gianluca Triolo; Claudio Schneider; Francesca Demarchi ABSTRACT CAPNS1 is essential for stability and function of the ubiquitous calcium-dependent proteases micro- and milli-calpain. Upon inhibition...