.... By manipulating metal ion content in the cornmeal diet, and measuring the metal content in each diet, we traced the difference in lifespan to the levels of calcium and magnesium in the food, suggesting that these ions are involved in Mn uptake and/or use. Based on these findings, it is recommended that the total...

...Katie M. Toperzer; Savannah J. Brennan; David J. Carroll; Eric A. Guisbert; Karen S. Kim Guisbert ABSTRACT Fertilization is a critical step in development, yet internal fertilization events are notoriously difficult to visualize. Taking advantage of the calcium response that is a hallmark of sperm...

...) of 4% (wt/vol) dextran sodium sulfate (DSS, FisherSci) separated by 1 week on regular drinking water. Rats were euthanized at 120, 150, or 180 days of age, depending on study needs. Breeder and study rats were fed an RD containing 2% calcium, 1.2% phosphorus, and 20% lactose (Envigo, Dublin, VA...

... that the regulation of mitochondrial dynamics is required for wound healing. By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced reactive oxygen species...

... and it was associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even...

.... Summary: Optimized potassium levels not only reduce malate levels but also improve fructose and sucrose accumulation in apple fruit. Apple fruit Calcium Malate Potassium Soluble sugar Apples (Malus domestica , Borkh.), belonging to the Rosaceae family, are one of the most important...

... secretion/deposition of collagen by the failing heart, the intracellular calcium dynamics, one of the main mediators of collagen secretion (Janssen et al., 2015), was compared between hVF-HF and the control. In fibroblasts, unlike excitable cells that require calcium influx through voltage-operated calcium...

... abnormalities, and elevated cytosolic calcium concentration. Here, we aim at better characterizing the calcium homeostasis impairment in extensor digitorum longus (EDL) and soleus muscles from adult HTZ KI- Dnm2 mice. We demonstrate abnormal contractile properties and cytosolic Ca 2+ concentration in EDL...

... of MICU2, with the associated conformational change governed by its first EF-hand, but not influenced by the C-helix domain. A disulfide bond and salt bridge each contribute to MICU1-MICU2 heterodimer formation. MICU1 MICU2 Calcium EF-hand Mitochondria More than half a century ago...

... but their physiological significance is unclear. Here we evaluated two different VEGF-A isoforms and discovered differential regulation of cytosolic calcium ion flux, transcription factor localisation and endothelial cell response. Analysis of VEGF-A isoform-specific stimulation of VEGFR2-dependent signal transduction...