...Jeannine A. Frei; Cheryl Brandenburg; Jonathan E. Nestor; Didier M. Hodzic; Celine Plachez; Helen McNeill; Derek M. Dykxhoorn; Michael W. Nestor; Gene J. Blatt; Yu-Chih Lin ABSTRACT Genetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD); however, the role...

... and strong cell–cell adhesion. Consistent with these observations, GFP–IIA− cells failed to assemble junction components such as E-cadherin, desmoplakin, and occludin at cell–cell contact sites. Therefore, IIA is required for assembly of junction complexes. MDCK cells with an ablation of the α-catenin gene...

...Masayuki Ozawa ABSTRACT Myoblast fusion is a highly regulated process that is essential for skeletal muscle formation during muscle development and regeneration in mammals. Much remains to be elucidated about the molecular mechanism of myoblast fusion although cadherins, which are Ca 2+ -dependent...

...Paul S. Murray; Ronen Zaidel-Bar ABSTRACT Vertebrate adherens junctions mediate cell–cell adhesion via a “classical” cadherin–catenin “core” complex, which is associated with and regulated by a functional network of proteins, collectively named the cadherin adhesome (“cadhesome”). The most basal...