... crypts of ionocytes. CFTR immunofluorescence was present in ionocyte apical crypts ( Fig. 8 B) where CFTR colocalized with Cldn-10c ( Fig. 8 C). In a different plane, distribution of Cldn-10c was further evident in the pavement cells and with prevalent immunofluorescence in the ionocyte apical crypts...

... of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, corrects CF Transmembrane conductance Regulator (CFTR)-dependent chloride transport in respiratory and intestinal tissues of F508del homozygous mice. Here, we studied the effect of vardenafil on CFTR in 16HBE14o – and CFBE41o − cell lines. First...

... to cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane and the sodium potassium 2 chloride cotransporter (NKCC) in the basolateral membrane. In FW acclimated fish, WNK1 localized to a sub-apical zone, did not colocalize with apical membrane-located sodium chloride cotransporter...

... polyphenol compound with antioxidant and anti-inflammatory properties, on CF transmembrane conductance regulator (CFTR) protein function. We assayed, in F508del-CFTR homozygous (CF) and in wild-type mice, the effect of resveratrol on salivary secretion in basal conditions, in response to inhibition...