... toolkit for Caenorhabditis elegans . Genetics 217 , iyab006 . 10.1093/genetics/iyab006 Austin , J. and Kimble , J. ( 1987 ). glp-1 Is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans . Cell 51 , 589 - 599 . 10.1016/0092...

... of knockdowns of its heterodimerizing bHLH partners. 37 bHLH factors were tested (out of the 42 bHLH factors present in the C. elegans genome; Grove et al., 2009 ) ( Table S1 ). The source of RNAi clones is indicated in Table S1 : Ahringer library, Vidal library, hlh-2 ( Karp and Greenwald, 2003...

... permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Neuronal expression of an ALS-associated mutation in a DNA/RNA-binding protein disrupts the organization and function of the C. elegans neuromuscular junction...

...Maria Gravato-Nobre; Jonathan Hodgkin; Petros Ligoxygakis ABSTRACT The nematode worm Caenorhabditis elegans depends on microbes in decaying vegetation as its food source. To survive in an environment rich in opportunistic pathogens, C . elegans has evolved an epithelial defence system where surface...

..., aggregates of PQN-75 are occasionally found throughout the pharynx, suggesting secretion from pharyngeal gland cells into the surrounding pharyngeal muscle. PQN-75 does not affect fertility and brood size in C. elegans but confers some degree of stress resistance and thermotolerance through unknown...

... and temporally regulate glutamylation remains relatively unexplored. We have undertaken an analysis of the glutamylating TTLL enzymes in C. elegans . We find that although all five TTLL enzymes are expressed in the embryo and adult worm, loss of individual enzymes does not perturb microtubule function...

.... K. , Gutierrez , E. , Zhang , K. , Noble , L. B. , Zanin , E. , Desai , A. , Groisman , A. and Oegema , K. ( 2011 ). Acute drug treatment in the early C. elegans embryo . PLoS ONE 6 , e24656 . 10.1371/journal.pone.0024656 Conduit , P. T. , Brunk , K...

... to screen a series of candidate substrates with heterologously expressed enzyme. An alternative and non-biased approach would be to employ a metabonomics-LC-MS-based system to interrogate C. elegans extracts following incubation with recombinant FMO-4 ( de Carvalho et al., 2010 ; Prosser et al., 2014...

...Tong Young Lee; Kyoung-hye Yoon; Jin Il Lee ABSTRACT The nematode Caenorhabditis elegans is one of the premier experimental model organisms today. In the laboratory, they display characteristic development, fertility, and behaviors in a two dimensional habitat. In nature, however, C. elegans...

... in glycopeptidolipid production is deficient in binding to human epithelial cells (HEp-2), as well as deficient in its ability to bind to and colonize the intestinal tract of C. elegans as efficiently as wild-type MAH. These data indicate the C. elegans may serve as a useful model system for MAH pathogenesis...

... a growing number of genes that promote the sperm/oocyte switch by acting genetically as upstream inhibitors of fem-3 . The wild-type C. elegans hermaphrodite, being able to produce both sperm and oocytes, is self-fertile. In an analysis of worms mutated for formin family genes, we had reported...

...Selma Waaijers; João Jacob Ramalho; Thijs Koorman; Elisabeth Kruse; Mike Boxem ABSTRACT Crumbs proteins are important regulators of epithelial polarity. In C. elegans , no essential role for the two described Crumbs homologs has been uncovered. Here, we identify and characterize an additional...

... in any medium provided that the original work is properly attributed. C. elegans molting larvae amyloid cuticle ABU/PQN innate immunity unfolded protein response Ecdysozoa, the clade of animals defined by the presence of an exoskeleton, exchange their cuticle during episodic molts...

... to touch and no pharyngeal pumping was observed. Worms that died because of bursting vulva were censored from further analysis. Differences in survival and lifespan of C. elegans between treatment (UE-12 or its bioactive compounds) group and control group (DMSO) in both wild-type and mutant animals were...

..., and apoptosis. Cooperative interactions between histone modifications such as acetylation, methylation and sumoylation are crucial for proper attenuation in C. elegans , implying that the proteins recognising these histone modifications could also play an important role in attenuation of RAS-mediated signalling...

.... , Zhang Y. , Herman M. A. , Okano H. , Sawa H. ( 2006 ). Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Dev. Cell 11 , 105 – 115 . 10.1016/j.devcel.2006.04.020 Blyth K...

... Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). C. elegans Centrosome Microtubules Mitotic spindle assembly PP2A Protein phosphatase Proteomics studies suggest that changes in protein phosphorylation are particularly...