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Keywords: Breast cancer
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Journal Articles
Biol Open (2020) 9 (1): bio047662.
Published: 24 January 2020
...Zi-Yan Yang; Liu Yang; Chun-Wei Xu; Xiao-Jia Wang; Lei Lei ABSTRACT In clinical practice, some breast cancer (BC) patients carry a rare ERBB2 in-frame insertion (p. Pro780_Tyr781insGlySerPro) and are resistant to anti-ERBB2 therapy. To explore the potential procarcinogenic role of this ERBB2...
Journal Articles
Biol Open (2019) 8 (11): bio045914.
Published: 6 November 2019
...Aizhu Duan; Lingmei Kong; Tao An; Hongyu Zhou; Chunlei Yu; Yan Li ABSTRACT Tumor protein D52 (TPD52) is an oncogene amplified and overexpressed in various cancers. Tumor-suppressive microRNA-449a and microRNA-34a (miR-449a/34a) were recently reported to inhibit breast cancer cell migration...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (7): bio040873.
Published: 28 June 2019
... wound healing, infection and inflammatory diseases. While the importance of CCL2/CCR2 signaling in macrophages during cancer progression is well documented, we recently showed that CCL2-mediated breast cancer progression depends on CCR2 expression in carcinoma cells. Using 3D Matrigel: Collagen cultures...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (4): bio038323.
Published: 18 April 2019
... been identified as an oncogene that modulates proliferation and migration of breast cancers (BC). ERBB2 is an oncogenic driver in 20–30% of BC in which its overexpression leads to increased chemoresistance. Here we investigated whether CHD4 depletion affects the ERBB2 cascade and autophagy, which...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (2): 176–186.
Published: 23 December 2016
... roles and regulation for PARN is beginning to be elucidated. Since phospholipase D (PLD2 isoform) gene expression is upregulated in breast cancer cells and PARN is downregulated, we examined whether a signaling connection existed between these two enzymes. Silencing PARN with siRNA led to an increase...
Journal Articles
Biol Open (2014) 3 (10): 937–946.
Published: 12 September 2014
...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Breast cancer Expression profiling Mouse tumor model Transcriptional regulation Wnt/β-Catenin pathway The Wnt/β-catenin signaling...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (7): 658–666.
Published: 25 May 2012
... ability to orchestrate key signal transduction events and promote cell motility. To identify novel downstream effectors of β4 function in breast cancer, microRNAs (miRNAs) were examined because of their extensive links to tumorigenesis and their ability to regulate gene expression globally. Two breast...
Includes: Supplementary data