... generates T null-like phenotypes suggestive of competition. T Tbx6 Brachyury Mouse T-box Mesoderm The T-box proteins constitute a family of transcription factors that are related through a shared DNA binding domain, the T-domain that allows family members to bind similar DNA sequences...

... work is properly attributed. Summary: Loss of SHH signaling is associated with the collapse of the sacral discs and formation of the sacrum. Conditional reactivation of SHH re-awakens the sacral disc, suggesting its potential for disc regeneration. SHH Brachyury SmoM2 Regeneration...

...Jing Zhou; Antonius Plagge; Patricia Murray ABSTRACT Mesodermal populations can be generated in vitro from mouse embryonic stem cells (mESCs) using three-dimensional (3-D) aggregates called embryoid bodies or two-dimensional (2-D) monolayer culture systems. Here, we investigated whether Brachyury...