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Keywords: Apoptosis
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Journal Articles
Biol Open (2021) 10 (4): bio058526.
Published: 23 April 2021
... progenitor cells for tissue and organ replacement. Branchial sac-derived stem cells also replenish recycling cells lining the pharyngeal fissures during homeostatic growth. Apoptosis at injury sites occurs early during regeneration and continuously in the pharyngeal fissures during homeostatic growth...
Journal Articles
Biol Open (2021) 10 (1): bio056796.
Published: 25 January 2021
... Apoptosis Entorhinal cortex Excitotoxicity Glia activation Inflammation Oxidative stress Tau Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in widespread neuropathology throughout the brain, and severe disruption of cognitive and mnemonic function ( Calderon...
Journal Articles
Biol Open (2020) 9 (12): bio051904.
Published: 21 December 2020
... proliferator-activated receptor β (PPARβ) was measured by RT-qPCR assay. The protein levels of PPARβ, α-SMA, Vimentin, COL1A, cyclin D1, bcl-2, and bax were detected by western blot assay. The effect of miR-9-5p and PPARβ on HS fibroblasts proliferation and apoptosis were detected by cell counting kit-8 (CCK-8...
Journal Articles
Biol Open (2020) 9 (3): bio048108.
Published: 30 March 2020
...Xuelian Su; Haijing Zhou; Guangjie Bao; Jizeng Wang; Lin Liu; Qian Zheng; Manli Guo; Jinting Zhang ABSTRACT Stem cell apoptosis exists widely in embryonic development, tissue regeneration, repair, aging and pathophysiology of disease. The molecular mechanism of stem cell apoptosis has been...
Journal Articles
Biol Open (2019) 8 (12): bio046524.
Published: 20 December 2019
...-protein response (UPR) in various tissues. The numbers of IPCs decreased owing to apoptosis induction mediated by caspases. The apoptosis was driven by activation of Dronc, and subsequently by Drice and Dcp-1. Accordingly, the relative mRNA-expression levels of Drosophila insulin-like peptides...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (12): bio039370.
Published: 11 December 2019
... apoptosis was enhanced by increasing concentration of oxygen. Interestingly, controlled reoxygenation inhibited neuron and glial cell apoptosis through suppressing cleavage of caspase-3 and PARP. We also found that controlled reoxygenation suppressed LCN2 expression and inflammatory cytokine (including TNF...
Journal Articles
Biol Open (2019) 8 (10): bio046417.
Published: 18 October 2019
... its expression and role in AML is still unexplored. Here, we show that SNHG1 is highly expressed in AML specimens from non-M3 patients, as well as AML cell lines. Meanwhile, upregulation of SNHG1 is correlated with poor prognosis. Notably, SNHG1 facilitates the proliferation and inhibits the apoptosis...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (8): bio043133.
Published: 16 August 2019
...Satomi Takao; Minoru Taya; Cerwyn Chiew ABSTRACT Providing an external mechanical stress to cancer cells seems to be an effective approach to treat cancer locally. Numbers of reports on cancer cell death subjected to mechanical stress loading are increasing, but they are more focused on apoptosis...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (8): bio036293.
Published: 28 August 2018
..., apoptosis seems to be primarily implicated in the removal of injured cells and tissue homeostasis. Little, however, is known about apoptotic pathways and control mechanisms. Therefore, here we provide additional information regarding the mechanisms of tissue degradation. Expression patterns of Bcl-2 family...
Journal Articles
Biol Open (2018) 7 (6): bio032045.
Published: 20 June 2018
...-dependent manner. Live BCG led to a higher DC survival compared with heat-killed BCG. FITC-Annexin V staining showed that BCG promoted DC survival by inhibiting apoptosis. Consistently, higher expressions of anti-apoptotic proteins Bcl-2 and Bcl-x L were observed in BCG-stimulated DCs. Pharmacological...
Journal Articles
Biol Open (2018) 7 (6): bio031815.
Published: 19 June 2018
...Stefan Washausen; Wolfgang Knabe ABSTRACT Placodes are focal thickenings of the surface ectoderm which, together with neural crest, generate the peripheral nervous system of the vertebrate head. Here we examine how, in embryonic mice, apoptosis contributes to the remodelling of the primordial...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (3): bio031765.
Published: 19 March 2018
...Jacqueline Ferralli; Richard P. Tucker; Ruth Chiquet-Ehrismann ABSTRACT Teneurins are type 2 transmembrane proteins expressed by developing neurons during periods of synaptogenesis and apoptosis. Neurons expressing teneurin-1 synapse with other teneurin-1-expressing neurons, and neurons expressing...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (1): bio027557.
Published: 17 January 2018
... mechanism in NKTCL remain unclear. We found that GSN overexpression significantly suppressed cell proliferation, colony formation and invasion, and promoted apoptosis of natural killer (NK) cell line YTS. Moreover, the upregulation of GSN significantly decreased the levels of PI3K and p-Akt. Interestingly...
Journal Articles
Biol Open (2017) 6 (12): 1897–1903.
Published: 21 November 2017
... in tumoral medium upregulated markers of a suboptimal condition, such as Sparc and TyrRS , and undergo apoptosis. However, M2 macrophages display higher Myc expression levels and proliferate at the expense of M1. Resulting M1 apoptotic debris is engulfed by M2 in a Sparc- and TyrRS-dependent manner...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (12): 1869–1875.
Published: 14 November 2017
... a central role in mitochondria-dependent apoptosis. Several lines of evidence have implied that Bax is involved in both epithelial apoptosis and fibroblast proliferation in idiopathic pulmonary fibrosis; however, the mechanisms remain unknown. Bax-inhibiting peptide V5 (BIP-V5) exhibits membrane...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (8): 1130–1136.
Published: 22 June 2017
... the expression levels of type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3 and MMP-13, but enhanced the expression of Runx1, type II collagen and aggrecan in the presence of IL-1β. Meanwhile, Tec inhibited apoptosis through the Bax/Bcl-2/caspase-3 pathway, upregulating p-Bad, downregulating...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (6): 732–740.
Published: 15 June 2017
... suggests that severe, non-lethal sepsis in mice results in significantly elevated hearing thresholds. A positive labelling for the pro-apoptotic markers BAX and Cleaved-caspase 3 suggested the induction of apoptosis in inner ear. * Author for correspondence ( Joachim.Schmutzhard@i-med.ac.at...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (9): 1260–1265.
Published: 19 August 2016
...′-untranslated region (3′-UTR) of SMO mRNA were predicted to have complementary binding regions. Accordingly, we inferred that miR-20a might act as a regulator of SMO, and regulate proliferation, differentiation and apoptosis in P19 cells. We determined the expression of miR-20a, SMO and marker proteins...
Journal Articles
Biol Open (2016) 5 (6): 794–800.
Published: 16 May 2016
... of this study was to investigate the biological roles of leptin and the mechanisms attributed to its action in non-small cell lung cancer (NSCLC) cell lines. The expression of leptin was measured by quantitative real-time PCR and western blot in seven NSCLC cell lines. Proliferation and apoptosis of NSCLC cells...
Journal Articles
Biol Open (2016) 5 (3): 367–371.
Published: 24 February 2016
...Fang Xiong; Lingqing Hu; Yun Zhang; Xiao Xiao; Juxia Xiao ABSTRACT Granulosa cell (GC) apoptosis has been shown to be involved in follicular atresia, which is a degenerative process in ovarian follicles of mammals. However, the mechanism underlying the regulation of follicular atresia, particularly...