...Johanna Örling; Katri Kosonen; Jenna Villman; Martin Reichard; Ilkka Paatero ABSTRACT Impaired wound healing is associated with aging and has significant effects on human health on an individual level, but also on the whole health-care sector. Deficient angiogenesis appears to be involved...

... response. Angiogenesis, or the formation of new blood vessels in the body is a well-coordinated multi-step process. Endothelial cells lining the blood vessels acquire several new properties such as front–rear polarity, invasiveness, rapid proliferation and motility during angiogenesis. This is achieved...

...Grace X. Li; Shaobing Zhang; Ren Liu; Bani Singh; Sukhmani Singh; David I. Quinn; Gage Crump; Parkash S. Gill ABSTRACT The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required for angiogenesis resulting in sprouting and pruning...

... microscopy (EM) Bevacizumab Angiogenesis Age-related macular degeneration (AMD) This model could also be used to study the formation of new healthy choroidal blood vessels in quiescent CNV. Such intact vessel formations have recently been suggested to have a protective effect in inhibiting the growth...

...Yihui Yang; Hongfu Yu; Congwen Yang; Yunfei Zhang; Xiangfa Ai; Xiaobo Wang; Kaizhi Lu; Bin Yi ABSTRACT Hepatopulmonary syndrome (HPS) is a serious pulmonary vascular disease derived from chronic liver disease, and its key pathogenesis is angiogenesis. Krüppel-like factor 6 (KLF6) mediates...

...Gareth W. Fearnley; Izma Abdul-Zani; Antony M. Latham; Monica C. Hollstein; John E. Ladbury; Stephen B. Wheatcroft; Adam F. Odell; Sreenivasan Ponnambalam ABSTRACT New blood vessel sprouting (angiogenesis) and vascular physiology are fundamental features of metazoan species but we do not fully...

... expressed proteins (DEPs) were identified and used for bioinformatics analysis. Interestingly, these proteins were implicated in epithelial mesenchymal transition (EMT), ECM-receptor interaction, focal adhesion, PI3K-Akt signaling pathway, angiogenesis and HIF-1 signaling pathway, which may play important...

... euthanized to measure vascular marker mRNA expression. We observed a significant increase in the expression of stem cell markers efnb2a , ephb4a , angiogenesis markers vegfa , kdrl , etv2 and lymphangiogenesis marker prox1 in the PGE2-group compared to the vehicle. This study shows the novel roles of PGE2...

... evokes different functional vascularization as assessed by CAM assay in ovo . ECM coating enhances vascularization compared to ECM-free hydroxyapatite. Perfusion culture Ceramic Elastic modulus Osteogenesis Angiogenesis CAM assay In maxillofacial and orthopaedic surgery, repair...

... to angiogenesis in monolayer culture. Because angiogenesis occurs in a three-dimensional (3D) environment, in this study we investigated the effects of a direct current (DC) electrical field (EF) on endothelial neovessel formation in 3D culture. There was a significant increase in tube formation when endothelial...

... cleavage events culminating in the nuclear accumulation of the Notch intracellular domain and its binding to a transcriptional co-factor to mediate gene expression. Notch signaling networks are essential regulators of vascular patterning and angiogenesis, as well as myriad other biological processes. Delta...

...Zaheer Ali; Anik Islam; Peter Sherrell; Mark Le-Moine; Georgios Lolas; Konstantinos Syrigos; Mehrdad Rafat; Lasse D. Jensen ABSTRACT Therapeutic induction of blood vessel growth (angiogenesis) in ischemic tissues holds great potential for treatment of myocardial infarction and stroke. Achieving...

...Masashi Maekawa; Kazufumi Tanigawa; Tomohisa Sakaue; Hiromi Hiyoshi; Eiji Kubota; Takashi Joh; Yuji Watanabe; Tomohiko Taguchi; Shigeki Higashiyama ABSTRACT Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is related to numerous pathophysiological events. We...

... defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) regulate signal transduction and angiogenesis, but how signaling and proteolysis is regulated is not well understood. Here, we provide evidence that a pathway requiring the E1 ubiquitin...

... show that AJAP1 attenuates sprouting angiogenesis by reducing endothelial migration and invasion capacities. Further, we show for the first time that endogenous AJAP1 is associated with the microtubule cytoskeleton. This linkage is independent from cell confluency and stable during angiogenic sprouting...

... and tumor-angiogenesis. Herein, we tested the involvement of classical cannabinoid receptors (CBRs) and the Ca 2+ -channel transient receptor potential vanilloid 1 (TRPV1) on cellular AEA uptake and its effect on endothelial cell proliferation and network-formation. Uptake of the fluorescence-labeled...

..., and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis...

... of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114 , 521 – 532 . Capurro M. I. , Xiang Y. Y. , Lobe C. , Filmus J. ( 2005 ). Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating...

... TLX, suggesting that TLX acts to maintain a hypoxic environment when HIF-2α is decreasing. Our results demonstrate TLX to play a key role in controlling angiogenesis by regulating HIF-2α. TLX and pVHL might counterbalance each other in important fate decisions such as self-renewal and differentiation...